Xanthoma of the Bone due to Type I Familial Hyperchylomicronemia Mimicking Malignant Bone Tumor with Secondary Aneurysmal-cystic Change
Xanthomas are commonly found in the soft tissues of hyperlipidemic patients. Rarely, they may involve the skeletal system, exhibiting various radiographic appearances that can mimic bone malignancies. A 55-year-old woman presented with back pain and bilateral lower limb weakness for several months....
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Formosan Journal of Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/fjmd.FJMD-D-23-00027 |
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| Summary: | Xanthomas are commonly found in the soft tissues of hyperlipidemic patients. Rarely, they may involve the skeletal system, exhibiting various radiographic appearances that can mimic bone malignancies. A 55-year-old woman presented with back pain and bilateral lower limb weakness for several months. Following a series of imaging studies, multifocal osteolytic lesions were identified in the pelvis and spine, with the largest measuring 94 mm in diameter. The final pathological diagnosis of bone xanthoma was confirmed, aided by an abnormal lipid profile and typical cutaneous presentation. Xanthoma of the bone may be confused with aggressive bone lesions radiologically. Clinical, laboratory, and physical findings in addition to pathological features are required to make an accurate diagnosis. |
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| ISSN: | 2210-7940 2210-7959 |