Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRI
Abstract Background Beta thalassemia major (β-TM) is a severe genetic anemia with considerable phenotypic heterogeneity. This study investigated whether genotype correlates with distinct myocardial iron overload patterns, assessed by cardiovascular magnetic resonance (CMR) T2* values. Methods CMR da...
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BMC
2025-01-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-025-01567-7 |
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| author | Siqi Zhang Wen Zhao Longwei Sun Guohua Liang Xiaodong Wang Hongwu Zeng |
| author_facet | Siqi Zhang Wen Zhao Longwei Sun Guohua Liang Xiaodong Wang Hongwu Zeng |
| author_sort | Siqi Zhang |
| collection | DOAJ |
| description | Abstract Background Beta thalassemia major (β-TM) is a severe genetic anemia with considerable phenotypic heterogeneity. This study investigated whether genotype correlates with distinct myocardial iron overload patterns, assessed by cardiovascular magnetic resonance (CMR) T2* values. Methods CMR data for cardiac iron deposition evaluation, which recruited pediatric participants between January 2021 and December 2024, were analyzed with CVI42. The patients were classified into three genetic subgroups of β0/β0, β0/β+, and β+/β+ based on their genetic outcomes. The CMR results classified patients into normal myocardial T2* value and myocardial iron overload groups. Qualitative and quantitative factors were subsequently compared by groups using comparative statistics. Results The study included 145 pediatric β-TM patients, with 24 (17%) exhibiting cardiac iron deposition based on CMR T2* values. There were significant differences in iron chelation treatment strategies across genotypes, with the β0/β0 genotype accounting for 54% (13/24) of patients in the cardiac iron deposition group. Regardless of genotype, the mid-inferolateral segment consistently showed the lowest CMR T2* values and the highest prevalence of iron deposition. Conclusion The risk of cardiac iron deposition increases as age progresses, and the mid-inferolateral segment is more susceptible to iron accumulation. The β0/β0 genotype is more likely to suffer from cardiac iron overload, emphasizing the need for closer clinical monitoring and regular cardiac MRI evaluations. |
| format | Article |
| id | doaj-art-c0b86fedc2334842bc2db96544326b8d |
| institution | Kabale University |
| issn | 1471-2342 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj-art-c0b86fedc2334842bc2db96544326b8d2025-02-02T12:47:54ZengBMCBMC Medical Imaging1471-23422025-01-0125111010.1186/s12880-025-01567-7Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRISiqi Zhang0Wen Zhao1Longwei Sun2Guohua Liang3Xiaodong Wang4Hongwu Zeng5Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical UniversityDepartment of Radiology, Shenzhen Children’s Hospital, Shantou University Medical CollegeDepartment of Radiology, Shenzhen Children’s Hospital, Shantou University Medical CollegeDepartment of Radiology, Shenzhen Children’s Hospital, Shantou University Medical CollegeDepartment of Hematology and Oncology, Shenzhen Children’s HospitalDepartment of Radiology, Shenzhen Children’s Hospital, Shantou University Medical CollegeAbstract Background Beta thalassemia major (β-TM) is a severe genetic anemia with considerable phenotypic heterogeneity. This study investigated whether genotype correlates with distinct myocardial iron overload patterns, assessed by cardiovascular magnetic resonance (CMR) T2* values. Methods CMR data for cardiac iron deposition evaluation, which recruited pediatric participants between January 2021 and December 2024, were analyzed with CVI42. The patients were classified into three genetic subgroups of β0/β0, β0/β+, and β+/β+ based on their genetic outcomes. The CMR results classified patients into normal myocardial T2* value and myocardial iron overload groups. Qualitative and quantitative factors were subsequently compared by groups using comparative statistics. Results The study included 145 pediatric β-TM patients, with 24 (17%) exhibiting cardiac iron deposition based on CMR T2* values. There were significant differences in iron chelation treatment strategies across genotypes, with the β0/β0 genotype accounting for 54% (13/24) of patients in the cardiac iron deposition group. Regardless of genotype, the mid-inferolateral segment consistently showed the lowest CMR T2* values and the highest prevalence of iron deposition. Conclusion The risk of cardiac iron deposition increases as age progresses, and the mid-inferolateral segment is more susceptible to iron accumulation. The β0/β0 genotype is more likely to suffer from cardiac iron overload, emphasizing the need for closer clinical monitoring and regular cardiac MRI evaluations.https://doi.org/10.1186/s12880-025-01567-7Β-thalassemia majorCardiac MRIIron depositionGenotypePaediatric |
| spellingShingle | Siqi Zhang Wen Zhao Longwei Sun Guohua Liang Xiaodong Wang Hongwu Zeng Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRI BMC Medical Imaging Β-thalassemia major Cardiac MRI Iron deposition Genotype Paediatric |
| title | Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRI |
| title_full | Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRI |
| title_fullStr | Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRI |
| title_full_unstemmed | Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRI |
| title_short | Assessment of cardiac iron deposition and genotypic classification in pediatric beta-thalassemia major: the role of cardiac MRI |
| title_sort | assessment of cardiac iron deposition and genotypic classification in pediatric beta thalassemia major the role of cardiac mri |
| topic | Β-thalassemia major Cardiac MRI Iron deposition Genotype Paediatric |
| url | https://doi.org/10.1186/s12880-025-01567-7 |
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