Impaired thyroid hormone receptor signaling in anterior hypothalamic parvalbumin neurons causes bradycardia in male mice

Impaired thyroid hormone receptor signaling in anterior hypothalamic parvalbumin neurons causes bradycardia in male mice

Thyroid hormone receptor α1 (TRα1) regulates body temperature and heart rate in humans and mice. In addition to its direct actions in target tissues, it also affects peripheral functions indirectly through the brain. While these central actions on peripheral tissues have been demonstrated for liver...

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Bibliographic Details
Main Authors: Beke Kolms, Riccardo Dore, Sarah C Sentis, Leonardo Vinicius Monteiro de Assis, Henrik Oster, Jens Mittag
Format: Article
Language:English
Published: Bioscientifica 2025-05-01
Series:European Thyroid Journal
Subjects:
thyroid hormone receptor
heart rate
rtha
Online Access:https://etj.bioscientifica.com/view/journals/etj/14/3/ETJ-25-0055.xml
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