Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia
Infection with HIV is known to increase the risk of cervical cancer. In addition, evidence suggests that concurrent infection with multiple human papillomavirus (HPV) genotypes increases the risk of cervical dysplasia more than infection with a single HPV genotype. However, the impact of the combina...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2016/7310894 |
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| _version_ | 1832560207808430080 |
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| author | David H. Adler Melissa Wallace Thola Bennie Beau Abar Tracy L. Meiring Anna-Lise Williamson Linda-Gail Bekker |
| author_facet | David H. Adler Melissa Wallace Thola Bennie Beau Abar Tracy L. Meiring Anna-Lise Williamson Linda-Gail Bekker |
| author_sort | David H. Adler |
| collection | DOAJ |
| description | Infection with HIV is known to increase the risk of cervical cancer. In addition, evidence suggests that concurrent infection with multiple human papillomavirus (HPV) genotypes increases the risk of cervical dysplasia more than infection with a single HPV genotype. However, the impact of the combination of HIV coinfection and presence of multiple concurrent HPV infections on the risk of cervical dysplasia is uncertain. We compared the results of HPV testing and Pap smears between HIV-infected and HIV-uninfected young women to assess the cumulative impact of these two conditions. We found that both HIV and the presence of multiple concurrent HPV infections are associated with increased risk of associated Pap smear abnormality and that the impact of these two risk factors may be additive. |
| format | Article |
| id | doaj-art-c0b480941bee4173b880f87d7b4efdcf |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-c0b480941bee4173b880f87d7b4efdcf2025-02-03T01:28:15ZengWileyAdvances in Virology1687-86391687-86472016-01-01201610.1155/2016/73108947310894Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical DysplasiaDavid H. Adler0Melissa Wallace1Thola Bennie2Beau Abar3Tracy L. Meiring4Anna-Lise Williamson5Linda-Gail Bekker6Department of Emergency Medicine, University of Rochester, Rochester, NY 14642, USADesmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South AfricaDesmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South AfricaDepartment of Emergency Medicine, University of Rochester, Rochester, NY 14642, USAInstitute of Infectious Diseases & Molecular Medicine and Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South AfricaInstitute of Infectious Diseases & Molecular Medicine and Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South AfricaDesmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South AfricaInfection with HIV is known to increase the risk of cervical cancer. In addition, evidence suggests that concurrent infection with multiple human papillomavirus (HPV) genotypes increases the risk of cervical dysplasia more than infection with a single HPV genotype. However, the impact of the combination of HIV coinfection and presence of multiple concurrent HPV infections on the risk of cervical dysplasia is uncertain. We compared the results of HPV testing and Pap smears between HIV-infected and HIV-uninfected young women to assess the cumulative impact of these two conditions. We found that both HIV and the presence of multiple concurrent HPV infections are associated with increased risk of associated Pap smear abnormality and that the impact of these two risk factors may be additive.http://dx.doi.org/10.1155/2016/7310894 |
| spellingShingle | David H. Adler Melissa Wallace Thola Bennie Beau Abar Tracy L. Meiring Anna-Lise Williamson Linda-Gail Bekker Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia Advances in Virology |
| title | Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia |
| title_full | Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia |
| title_fullStr | Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia |
| title_full_unstemmed | Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia |
| title_short | Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia |
| title_sort | cumulative impact of hiv and multiple concurrent human papillomavirus infections on the risk of cervical dysplasia |
| url | http://dx.doi.org/10.1155/2016/7310894 |
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