Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data.
Over the last decade the availability of SNP-trait associations from genome-wide association studies has led to an array of methods for performing Mendelian randomization studies using only summary statistics. A common feature of these methods, besides their intuitive simplicity, is the ability to c...
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| Main Authors: | Ciarrah Barry, Junxi Liu, Rebecca Richmond, Martin K Rutter, Deborah A Lawlor, Frank Dudbridge, Jack Bowden |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-08-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009703&type=printable |
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