Rutin attenuates complete Freund’s adjuvant-induced inflammatory pain in rats
Objective(s): Rutin is a bioflavonoid compound renowned for its anti-oxidative, anti-inflammatory, and antinociceptive properties. The present study aims to assess its therapeutic efficacy on complete Freund’s adjuvant (CFA)‑induced inflammatory pain. Materials and Methods: Arthritis was induced in...
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Mashhad University of Medical Sciences
2025-03-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_25359_35bb9c0d93c15deca970b4ad5ebac5f3.pdf |
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| author | Fatemeh Forouzanfar Ali Mohammad Pourbagher-Shahri Amir Mahmoud Ahmadzadeh |
| author_facet | Fatemeh Forouzanfar Ali Mohammad Pourbagher-Shahri Amir Mahmoud Ahmadzadeh |
| author_sort | Fatemeh Forouzanfar |
| collection | DOAJ |
| description | Objective(s): Rutin is a bioflavonoid compound renowned for its anti-oxidative, anti-inflammatory, and antinociceptive properties. The present study aims to assess its therapeutic efficacy on complete Freund’s adjuvant (CFA)‑induced inflammatory pain. Materials and Methods: Arthritis was induced in Wistar rats via subcutaneous administration of CFA into the right hind paw. Rutin (15 and 30 mg/kg) and indomethacin (5 mg/kg, orally) were given once daily for three weeks. Parameters observed included alterations in paw swelling perimeter, arthritis scores, and body weight. Additionally, antinociceptive activity was measured through thermal hyperalgesia and cold allodynia responses. The Tumor necrosis factor-alpha (TNF-α) level in the serum was measured. Malondialdehyde (MDA), thiol levels, catalase, and superoxide dismutase (SOD) activities were also evaluated as serum oxidative stress markers. Results: Rutin and indomethacin significantly suppressed alterations in paw edema, pain responses, and arthritis scores and reduced the loss of body weight in contrast to disease-control rats. Furthermore, in contrast to disease control rats, rutin and indomethacin treatment exhibited an anti-inflammatory effect through a marked reduction in TNF-α levels in the serum. Rutin and indomethacin demonstrated a significant increase in catalase and SOD activities, a total thiol level, and a decrease in MDA level compared to the disease-control rats.Conclusion: These results suggest that rutin’s antiarthritic effect is mediated by its antinociceptive, anti-oxidant, and anti-inflammatory properties. |
| format | Article |
| id | doaj-art-c090a8071c9e4615a598be80b3fedfa0 |
| institution | DOAJ |
| issn | 2008-3866 2008-3874 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj-art-c090a8071c9e4615a598be80b3fedfa02025-08-20T03:08:50ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742025-03-0128333233910.22038/ijbms.2024.81572.1765525359Rutin attenuates complete Freund’s adjuvant-induced inflammatory pain in ratsFatemeh Forouzanfar0Ali Mohammad Pourbagher-Shahri1Amir Mahmoud Ahmadzadeh2Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMedical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Radiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranObjective(s): Rutin is a bioflavonoid compound renowned for its anti-oxidative, anti-inflammatory, and antinociceptive properties. The present study aims to assess its therapeutic efficacy on complete Freund’s adjuvant (CFA)‑induced inflammatory pain. Materials and Methods: Arthritis was induced in Wistar rats via subcutaneous administration of CFA into the right hind paw. Rutin (15 and 30 mg/kg) and indomethacin (5 mg/kg, orally) were given once daily for three weeks. Parameters observed included alterations in paw swelling perimeter, arthritis scores, and body weight. Additionally, antinociceptive activity was measured through thermal hyperalgesia and cold allodynia responses. The Tumor necrosis factor-alpha (TNF-α) level in the serum was measured. Malondialdehyde (MDA), thiol levels, catalase, and superoxide dismutase (SOD) activities were also evaluated as serum oxidative stress markers. Results: Rutin and indomethacin significantly suppressed alterations in paw edema, pain responses, and arthritis scores and reduced the loss of body weight in contrast to disease-control rats. Furthermore, in contrast to disease control rats, rutin and indomethacin treatment exhibited an anti-inflammatory effect through a marked reduction in TNF-α levels in the serum. Rutin and indomethacin demonstrated a significant increase in catalase and SOD activities, a total thiol level, and a decrease in MDA level compared to the disease-control rats.Conclusion: These results suggest that rutin’s antiarthritic effect is mediated by its antinociceptive, anti-oxidant, and anti-inflammatory properties.https://ijbms.mums.ac.ir/article_25359_35bb9c0d93c15deca970b4ad5ebac5f3.pdfanti-inflammatoryanti-oxidantpainrheumatoid arthritisrutin |
| spellingShingle | Fatemeh Forouzanfar Ali Mohammad Pourbagher-Shahri Amir Mahmoud Ahmadzadeh Rutin attenuates complete Freund’s adjuvant-induced inflammatory pain in rats Iranian Journal of Basic Medical Sciences anti-inflammatory anti-oxidant pain rheumatoid arthritis rutin |
| title | Rutin attenuates complete Freund’s adjuvant-induced inflammatory pain in rats |
| title_full | Rutin attenuates complete Freund’s adjuvant-induced inflammatory pain in rats |
| title_fullStr | Rutin attenuates complete Freund’s adjuvant-induced inflammatory pain in rats |
| title_full_unstemmed | Rutin attenuates complete Freund’s adjuvant-induced inflammatory pain in rats |
| title_short | Rutin attenuates complete Freund’s adjuvant-induced inflammatory pain in rats |
| title_sort | rutin attenuates complete freund s adjuvant induced inflammatory pain in rats |
| topic | anti-inflammatory anti-oxidant pain rheumatoid arthritis rutin |
| url | https://ijbms.mums.ac.ir/article_25359_35bb9c0d93c15deca970b4ad5ebac5f3.pdf |
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