Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes

Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes

Background: Age-related hearing loss (ARHL) is a common sensory disorder with significant public health implications. However, few effective treatment options are available. Mendelian randomization (MR) has been used to repurpose existing drugs and identify new therapeutic targets. Therefore, we per...

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Bibliographic Details
Main Authors: Kun Zhang, Bo Hou, Tao Yan, Ruru Qiao, Peng Qu, Xinbo Xu, Hanbing Zhang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Experimental Gerontology
Subjects:
ARHL
Mendelian randomization
Druggable target genes
Colocalization analyses
Online Access:http://www.sciencedirect.com/science/article/pii/S053155652500004X
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