Sexual Differences in response to Mid- or Low-Premixed Insulin Analogue in Patients with Type 2 Diabetes
Objective. To observe whether there are sexual-related differences in response to mid- or low-premixed insulin in type 2 diabetic patients. Methods. This was an analysis of CGM data of a previous study. After screening, patients with longstanding T2D receive a 7-day continuous subcutaneous insulin i...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8152640 |
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| author | Bing-li Liu Xiao-mei Liu Yi-fei Ren Yi-Xuan Sun Meng-hui Luo Lei Ye Jian-hua Ma Feng-fei Li |
| author_facet | Bing-li Liu Xiao-mei Liu Yi-fei Ren Yi-Xuan Sun Meng-hui Luo Lei Ye Jian-hua Ma Feng-fei Li |
| author_sort | Bing-li Liu |
| collection | DOAJ |
| description | Objective. To observe whether there are sexual-related differences in response to mid- or low-premixed insulin in type 2 diabetic patients. Methods. This was an analysis of CGM data of a previous study. After screening, patients with longstanding T2D receive a 7-day continuous subcutaneous insulin infusion (CSII) therapy, and then subjects were randomly assigned 1 : 1 into two groups receiving Novo Mix 30 or Humalog Mix 50 regimen for a 2-day phage, followed by a 4-day cross-over period. A 4-day continuous glucose monitoring (CGM) was performed during the cross-over period. The primary endpoint was the differences in glycemic control between male and female patients receiving mid- or low-premixed insulin therapy. Results. A total of 102 patients (52 men and 50 women) completed the study. Our data showed that male patients had significant decrease in mean glucose levels monitored by CGM after three meals during Humalog Mix 50 treatment period compared to those received Novo Mix 30 regimen (0900: 11.0±2.5 vs. 12.2±2.8, 1000: 9.9±2.9 vs. 11.3±3.1, 1200: 8.0±1.9 vs. 9.1±2.5, 1400: 9.2±2.3 vs. 10.3±2.5, and 2000: 7.3±2.1 vs. 8.2±2.4 mmol/L, p<0.05, respectively). In addition, male patients receiving Novo Mix 30 experienced a significantly increased hypoglycemic duration compared to those of receiving Humalog Mix 50 (0 (0, 4.8) vs. 0 (0, 0), p<0.05). Conclusion. Our data indicate that male patients with T2D receiving mid-premixed insulin analogue regimen may have a potential benefit of improvement in glycemic control compared to female patients. This trial is registered with ClinicalTrials.gov ChiCTR-IPR-15007340. |
| format | Article |
| id | doaj-art-c06dabe32b1d45c3b2b663df8f24b3e0 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c06dabe32b1d45c3b2b663df8f24b3e02025-02-03T05:44:15ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/81526408152640Sexual Differences in response to Mid- or Low-Premixed Insulin Analogue in Patients with Type 2 DiabetesBing-li Liu0Xiao-mei Liu1Yi-fei Ren2Yi-Xuan Sun3Meng-hui Luo4Lei Ye5Jian-hua Ma6Feng-fei Li7Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaNational Heart Research Institute Singapore, National Heart Centre Singapore, SingaporeDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaObjective. To observe whether there are sexual-related differences in response to mid- or low-premixed insulin in type 2 diabetic patients. Methods. This was an analysis of CGM data of a previous study. After screening, patients with longstanding T2D receive a 7-day continuous subcutaneous insulin infusion (CSII) therapy, and then subjects were randomly assigned 1 : 1 into two groups receiving Novo Mix 30 or Humalog Mix 50 regimen for a 2-day phage, followed by a 4-day cross-over period. A 4-day continuous glucose monitoring (CGM) was performed during the cross-over period. The primary endpoint was the differences in glycemic control between male and female patients receiving mid- or low-premixed insulin therapy. Results. A total of 102 patients (52 men and 50 women) completed the study. Our data showed that male patients had significant decrease in mean glucose levels monitored by CGM after three meals during Humalog Mix 50 treatment period compared to those received Novo Mix 30 regimen (0900: 11.0±2.5 vs. 12.2±2.8, 1000: 9.9±2.9 vs. 11.3±3.1, 1200: 8.0±1.9 vs. 9.1±2.5, 1400: 9.2±2.3 vs. 10.3±2.5, and 2000: 7.3±2.1 vs. 8.2±2.4 mmol/L, p<0.05, respectively). In addition, male patients receiving Novo Mix 30 experienced a significantly increased hypoglycemic duration compared to those of receiving Humalog Mix 50 (0 (0, 4.8) vs. 0 (0, 0), p<0.05). Conclusion. Our data indicate that male patients with T2D receiving mid-premixed insulin analogue regimen may have a potential benefit of improvement in glycemic control compared to female patients. This trial is registered with ClinicalTrials.gov ChiCTR-IPR-15007340.http://dx.doi.org/10.1155/2020/8152640 |
| spellingShingle | Bing-li Liu Xiao-mei Liu Yi-fei Ren Yi-Xuan Sun Meng-hui Luo Lei Ye Jian-hua Ma Feng-fei Li Sexual Differences in response to Mid- or Low-Premixed Insulin Analogue in Patients with Type 2 Diabetes Journal of Diabetes Research |
| title | Sexual Differences in response to Mid- or Low-Premixed Insulin Analogue in Patients with Type 2 Diabetes |
| title_full | Sexual Differences in response to Mid- or Low-Premixed Insulin Analogue in Patients with Type 2 Diabetes |
| title_fullStr | Sexual Differences in response to Mid- or Low-Premixed Insulin Analogue in Patients with Type 2 Diabetes |
| title_full_unstemmed | Sexual Differences in response to Mid- or Low-Premixed Insulin Analogue in Patients with Type 2 Diabetes |
| title_short | Sexual Differences in response to Mid- or Low-Premixed Insulin Analogue in Patients with Type 2 Diabetes |
| title_sort | sexual differences in response to mid or low premixed insulin analogue in patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2020/8152640 |
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