Disrupting Notch signaling related HES1 in myeloid cells reinvigorates antitumor T cell responses

Disrupting Notch signaling related HES1 in myeloid cells reinvigorates antitumor T cell responses

Abstract Background Tumor-associated macrophages (TAMs) are immunosuppressive cells within the tumor microenvironment (TME) that hinder anti-tumor immunity. Notch signaling is a pathway crucial for TAM differentiation and function. Here, we investigate the role of HES1, a downstream target of Notch...

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Main Authors: Myung Sup Kim, Hyeokgu Kang, Jung-Hwan Baek, Moon-Gyu Cho, Eun Joo Chung, Seok-Jun Kim, Joon-Yong Chung, Kyung-Hee Chun
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Experimental Hematology & Oncology
Online Access:https://doi.org/10.1186/s40164-024-00588-2
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