Disrupting Notch signaling related HES1 in myeloid cells reinvigorates antitumor T cell responses
Abstract Background Tumor-associated macrophages (TAMs) are immunosuppressive cells within the tumor microenvironment (TME) that hinder anti-tumor immunity. Notch signaling is a pathway crucial for TAM differentiation and function. Here, we investigate the role of HES1, a downstream target of Notch...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
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| Series: | Experimental Hematology & Oncology |
| Online Access: | https://doi.org/10.1186/s40164-024-00588-2 |
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