Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA [version 3; peer review: 1 approved, 3 approved with reservations, 1 not approved]

Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA [version 3; peer review: 1 approved, 3 approved with reservations, 1 not approved]

Background Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ), the long-acting components of the artemisinin-based combination therapies (ACTs), are a cornerstone of malaria treatment in Africa. Studies have shown that PQ, AQ, and LM resistance may arise independently of predicted modes of ac...

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Bibliographic Details
Main Authors: Peter Mwitari, Francis Kimani, Daniel Kiboi, Brenda Muriithi, Jean Chepngetich, Kevin Thiong'o, Beatrice Gachie, Jeremiah Gathirwa, Mercy Jepkorir
Format: Article
Language:English
Published: F1000 Research Ltd 2023-10-01
Series:Open Research Africa
Subjects:
Lumefantrine
Piperaquine
Amodiaquine
Resistance
Plasmodium berghei
kinase
eng
Online Access:https://openresearchafrica.org/articles/5-28/v3
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