The Levels of Adhesion Molecules in Essential Thrombocythemia
Background: It is known that thrombocytosis is closely related to vascular complications and particularly thrombosis in essential thrombocytemia (ET) cases. The aim of this study is to investigate a possible correlation between adhesion molecules and vascular attacks as well as the relation of these...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1738 |
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| Summary: | Background: It is known that thrombocytosis is closely related to vascular complications and particularly thrombosis in essential thrombocytemia (ET) cases. The aim of this study is to investigate a possible correlation between adhesion molecules and vascular attacks as well as the relation of these molecules to the platelet count.
Material and Methods: The study group consisted of 30 essential thrombocythemia patients and 30 healthy controls subjects. Serum intracellular adhesion molecule-1 (ICAM-1), serum vascular adhesion molecule-1 (VCAM-1) and serum E-selectin levels were determined by ELISA method according to manufacturer’s instructions.
Results: There were no significant differences between two groups with respect to levels of sICAM-1 and sE-selectin (p>0.05). The VCAM-1 levels and platelets were significantly higher in patients with ET compared to controls (p=0.000). Spearman’s correlation analysis revealed that sVCAM-1 levels were correlated with platelet counts (r=0.574, p<0.001)
Conclusions: High VCAM-1 level in Essential Thrombocytosis and its correlation with the platelet count suggest that these may be a factor in vascular complications and thrombocytosis. |
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| ISSN: | 2035-3006 |