EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation
EXPAREL® has been used successfully to prolong postoperative pain control when applied as a wound infiltrate. EXPAREL® has not yet been approved for use in regional anesthesia to prolong postoperative pain control. We conducted a clinical case series of 4 patients using EXPAREL® for sciatic blocks v...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2020/5982567 |
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| author | Patrick Discepola Mohamed Bouhara Minho Kwon Bilal A. Siddiqui Trevor A. Whitwell Swetha Y. Sanghvi Keith D. Cook Ross E. Moore Anna Korban Jean D. Eloy |
| author_facet | Patrick Discepola Mohamed Bouhara Minho Kwon Bilal A. Siddiqui Trevor A. Whitwell Swetha Y. Sanghvi Keith D. Cook Ross E. Moore Anna Korban Jean D. Eloy |
| author_sort | Patrick Discepola |
| collection | DOAJ |
| description | EXPAREL® has been used successfully to prolong postoperative pain control when applied as a wound infiltrate. EXPAREL® has not yet been approved for use in regional anesthesia to prolong postoperative pain control. We conducted a clinical case series of 4 patients using EXPAREL® for sciatic blocks via the popliteal fossa approach. Our results suggested that there is a large degree of variability in response to the medication. These inconsistent results and the possibility of bimodal kinetics creating analgesic gaps as seen in two of our patients indicate that more studies with larger sample size are needed to better characterize these phenomena and determine if more consistent results can be obtained in a future clinical trial. |
| format | Article |
| id | doaj-art-c050e79e682a4ce6aa7801e399256494 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-c050e79e682a4ce6aa7801e3992564942025-02-03T01:00:09ZengWileyPain Research and Management1203-67651918-15232020-01-01202010.1155/2020/59825675982567EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture FixationPatrick Discepola0Mohamed Bouhara1Minho Kwon2Bilal A. Siddiqui3Trevor A. Whitwell4Swetha Y. Sanghvi5Keith D. Cook6Ross E. Moore7Anna Korban8Jean D. Eloy9Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USAAnesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USAAnesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USAAnesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USAAnesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USAAnesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USAPodiatry, University Hospital, Newark, NJ, USAAnesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USAAnesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USAAnesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USAEXPAREL® has been used successfully to prolong postoperative pain control when applied as a wound infiltrate. EXPAREL® has not yet been approved for use in regional anesthesia to prolong postoperative pain control. We conducted a clinical case series of 4 patients using EXPAREL® for sciatic blocks via the popliteal fossa approach. Our results suggested that there is a large degree of variability in response to the medication. These inconsistent results and the possibility of bimodal kinetics creating analgesic gaps as seen in two of our patients indicate that more studies with larger sample size are needed to better characterize these phenomena and determine if more consistent results can be obtained in a future clinical trial.http://dx.doi.org/10.1155/2020/5982567 |
| spellingShingle | Patrick Discepola Mohamed Bouhara Minho Kwon Bilal A. Siddiqui Trevor A. Whitwell Swetha Y. Sanghvi Keith D. Cook Ross E. Moore Anna Korban Jean D. Eloy EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation Pain Research and Management |
| title | EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation |
| title_full | EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation |
| title_fullStr | EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation |
| title_full_unstemmed | EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation |
| title_short | EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation |
| title_sort | exparel r long acting liposomal bupivacaine use for popliteal nerve block in postoperative pain control after ankle fracture fixation |
| url | http://dx.doi.org/10.1155/2020/5982567 |
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