Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces

Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces

Antibody-mediated delivery of immunogenic viral CD8+ T-cell epitopes to redirect virus-specific T cells toward cancer cells is a promising new therapeutic avenue to increase the immunogenicity of tumors. Multiple strategies for viral epitope delivery have been shown to be effective. So far, most of...

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Bibliographic Details
Main Authors: W. van der Wulp, W. Luu, M. E. Ressing, J. Schuurman, S. I. van Kasteren, L. Guelen, R. C. Hoeben, B. Bleijlevens, M. H. M. Heemskerk
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
antibody-epitope conjugates (AECs)
virus-specific T-cells
immunotherapy
redirecting T-cells
bispecific-antibodies
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2329321
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