Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation
A series of new 4-thiazolidinone derivatives was synthesized, characterized by spectral techniques, and screened for antimicrobial activity. All the compounds were evaluated against five Gram-positive bacteria, two Gram-negative bacteria, and two fungi, at concentrations of 50, 100, 200, 400, 800, a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2016/8086762 |
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| author | Amit Gupta Rajendra Singh Pankaj K. Sonar Shailendra K. Saraf |
| author_facet | Amit Gupta Rajendra Singh Pankaj K. Sonar Shailendra K. Saraf |
| author_sort | Amit Gupta |
| collection | DOAJ |
| description | A series of new 4-thiazolidinone derivatives was synthesized, characterized by spectral techniques, and screened for antimicrobial activity. All the compounds were evaluated against five Gram-positive bacteria, two Gram-negative bacteria, and two fungi, at concentrations of 50, 100, 200, 400, 800, and 1600 µg/mL, respectively. Minimum inhibitory concentrations of all the compounds were also determined and were found to be in the range of 100–400 µg/mL. All the compounds showed moderate-to-good antimicrobial activity. Compounds 4a [2-(4-fluoro-phenyl)-3-(4-methyl-5,6,7,8-tetrahydro-quinazolin-2-yl)-thiazolidin-4-one] and 4e [3-(4,6-dimethyl-pyrimidin-2-yl)-2-(2-methoxy-phenyl)-thiazolidin-4-one] were the most potent compounds of the series, exhibiting marked antimicrobial activity against Pseudomonas fluorescens, Staphylococcus aureus, and the fungal strains. Thus, on the basis of results obtained, it may be concluded that synthesized compounds exhibit a broad spectrum of antimicrobial activity. |
| format | Article |
| id | doaj-art-c04a73a6353b46b7b90d9311f6b0c58c |
| institution | OA Journals |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-c04a73a6353b46b7b90d9311f6b0c58c2025-08-20T02:19:26ZengWileyBiochemistry Research International2090-22472090-22552016-01-01201610.1155/2016/80867628086762Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial EvaluationAmit Gupta0Rajendra Singh1Pankaj K. Sonar2Shailendra K. Saraf3Faculty of Pharmacy, Babu Banarasi Das Northern India Institute of Technology, Sector-II, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow, Uttar Pradesh 227105, IndiaFaculty of Pharmacy, Babu Banarasi Das Northern India Institute of Technology, Sector-II, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow, Uttar Pradesh 227105, IndiaFaculty of Pharmacy, Babu Banarasi Das Northern India Institute of Technology, Sector-II, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow, Uttar Pradesh 227105, IndiaFaculty of Pharmacy, Babu Banarasi Das Northern India Institute of Technology, Sector-II, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow, Uttar Pradesh 227105, IndiaA series of new 4-thiazolidinone derivatives was synthesized, characterized by spectral techniques, and screened for antimicrobial activity. All the compounds were evaluated against five Gram-positive bacteria, two Gram-negative bacteria, and two fungi, at concentrations of 50, 100, 200, 400, 800, and 1600 µg/mL, respectively. Minimum inhibitory concentrations of all the compounds were also determined and were found to be in the range of 100–400 µg/mL. All the compounds showed moderate-to-good antimicrobial activity. Compounds 4a [2-(4-fluoro-phenyl)-3-(4-methyl-5,6,7,8-tetrahydro-quinazolin-2-yl)-thiazolidin-4-one] and 4e [3-(4,6-dimethyl-pyrimidin-2-yl)-2-(2-methoxy-phenyl)-thiazolidin-4-one] were the most potent compounds of the series, exhibiting marked antimicrobial activity against Pseudomonas fluorescens, Staphylococcus aureus, and the fungal strains. Thus, on the basis of results obtained, it may be concluded that synthesized compounds exhibit a broad spectrum of antimicrobial activity.http://dx.doi.org/10.1155/2016/8086762 |
| spellingShingle | Amit Gupta Rajendra Singh Pankaj K. Sonar Shailendra K. Saraf Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation Biochemistry Research International |
| title | Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation |
| title_full | Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation |
| title_fullStr | Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation |
| title_full_unstemmed | Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation |
| title_short | Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation |
| title_sort | novel 4 thiazolidinone derivatives as anti infective agents synthesis characterization and antimicrobial evaluation |
| url | http://dx.doi.org/10.1155/2016/8086762 |
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