Beyond platelet activation: dysregulated lipid metabolism in defining risk and pathophysiology of VITT

Beyond platelet activation: dysregulated lipid metabolism in defining risk and pathophysiology of VITT

Background: VITT has emerged as a rare but serious adverse event linked primarily to adenoviral vector COVID-19 vaccinations, such as ChAdOx1-S (Oxford/AstraZeneca) vaccination. The syndrome is characterized by thrombosis with thrombocytopenia, elevated D-dimer, and pathologic platelet factor 4 anti...

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Main Authors: Hannah Stevens, James D. McFadyen, Natalie A. Mellett, David J. Lynn, Thy Duong, Corey Giles, Jane James, Rochelle Botten, Georgina Eden, Miriam Lynn, Paul Monagle, Peter J. Meikle, Sanjeev Chunilal, Karlheinz Peter, Huyen Tran
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
lipidomics
mass spectrometry
platelet activation
thrombosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2475037925000019
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