Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle

Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle

Abstract Stem cells show intrinsic interferon signalling, which protects them from viral infections at all ages. In the ageing brain, interferon signalling also reduces the ability of stem cells to activate. Whether these functions are linked and at what time interferons start taking on a role in st...

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Bibliographic Details
Main Authors: Damian Carvajal Ibañez, Maxim Skabkin, Jooa Hooli, Santiago Cerrizuela, Manuel Göpferich, Adrien Jolly, Katrin Volk, Marc Zumwinkel, Matilde Bertolini, Gianluca Figlia, Thomas Höfer, Guenter Kramer, Simon Anders, Aurelio A Teleman, Anna Marciniak‐Czochra, Ana Martin‐Villalba
Format: Article
Language:English
Published: Springer Nature 2023-01-01
Series:EMBO Molecular Medicine
Subjects:
ageing
dormancy
interferon
mTOR
stem cells
Online Access:https://doi.org/10.15252/emmm.202216434
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