Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer’s disease

Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer’s disease

Abstract Disease-Associated Microglia (DAM) are a focus in Alzheimer’s disease (AD) research due to their central involvement in the response to amyloid-beta plaques. Microglial Toll-like receptor 4 (TLR4) is instrumental in the binding of fibrillary amyloid proteins, while Lyn kinase (Lyn) is a mem...

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Bibliographic Details
Main Authors: Rezwanul Islam, Hadi Hasan Choudhary, Feng Zhang, Hritik Mehta, Jun Yoshida, Ajith J. Thomas, Khalid Hanafy
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
Disease-Associated Microglia
TLR4
Lyn kinase
TLR4-Lyn modulator protein
5XFAD
Online Access:https://doi.org/10.1038/s41598-025-96456-y
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