Biologic Agents in Crohn’s Patients Reduce CD4+ T Cells Activation and Are Inversely Related to Treg Cells
Crohn’s disease (CD) is a chronic inflammatory disease with a complex interface of broad factors. There are two main treatments for Chron’s disease: biological therapy and nonbiological therapy. Biological agent therapy (e.g., anti-TNF) is the most frequently prescribed treatment; however, it is not...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2022/1307159 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554730777214976 |
|---|---|
| author | Eliane Aparecida Rosseto-Welter Leticia D’argenio-Garcia Filipa Blasco Tavares Pereira Lopes Ana Eduarda Zulim Carvalho Fernando Flaquer Vanessa Severo-Lemos Claudia Concer Viero Nora Flavio Steinwurz Lucas Pires Garcia Oliveria Thiago Aloia Luiz Vicente Rizzo Cristóvão Luis Pitangueira Mangueira Karina Inacio Carvalho |
| author_facet | Eliane Aparecida Rosseto-Welter Leticia D’argenio-Garcia Filipa Blasco Tavares Pereira Lopes Ana Eduarda Zulim Carvalho Fernando Flaquer Vanessa Severo-Lemos Claudia Concer Viero Nora Flavio Steinwurz Lucas Pires Garcia Oliveria Thiago Aloia Luiz Vicente Rizzo Cristóvão Luis Pitangueira Mangueira Karina Inacio Carvalho |
| author_sort | Eliane Aparecida Rosseto-Welter |
| collection | DOAJ |
| description | Crohn’s disease (CD) is a chronic inflammatory disease with a complex interface of broad factors. There are two main treatments for Chron’s disease: biological therapy and nonbiological therapy. Biological agent therapy (e.g., anti-TNF) is the most frequently prescribed treatment; however, it is not universally accessible. In fact, in Brazil, many patients are only given the option of receiving nonbiological therapy. This approach prolongs the subsequent clinical relapse; however, this procedure could be implicated in the immune response and enhance disease severity. Our purpose was to assess the effects of different treatments on CD4+ T cells in a cohort of patients with Crohn’s disease compared with healthy individuals. To examine the immune status in a Brazilian cohort, we analyzed CD4+ T cells, activation status, cytokine production, and Treg cells in blood of Crohn’s patients. Patients that underwent biological therapy can recover the percentage of CD4+CD73+ T cells, decrease the CD4+ T cell activation/effector functions, and maintain the peripheral percentage of regulatory T cells. These results show that anti-TNF agents can improve CD4+ T cell subsets, thereby inducing Crohn’s patients to relapse and remission rates. |
| format | Article |
| id | doaj-art-c02880b0ac524b9bb2c25993484305cd |
| institution | Kabale University |
| issn | 2291-2797 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-c02880b0ac524b9bb2c25993484305cd2025-02-03T05:50:44ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27972022-01-01202210.1155/2022/1307159Biologic Agents in Crohn’s Patients Reduce CD4+ T Cells Activation and Are Inversely Related to Treg CellsEliane Aparecida Rosseto-Welter0Leticia D’argenio-Garcia1Filipa Blasco Tavares Pereira Lopes2Ana Eduarda Zulim Carvalho3Fernando Flaquer4Vanessa Severo-Lemos5Claudia Concer Viero Nora6Flavio Steinwurz7Lucas Pires Garcia Oliveria8Thiago Aloia9Luiz Vicente Rizzo10Cristóvão Luis Pitangueira Mangueira11Karina Inacio Carvalho12Hospital Israelita Albert EinsteinHospital Israelita Albert EinsteinCase Western Reserve UniversityHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinHospital Israelita Albert EinsteinCrohn’s disease (CD) is a chronic inflammatory disease with a complex interface of broad factors. There are two main treatments for Chron’s disease: biological therapy and nonbiological therapy. Biological agent therapy (e.g., anti-TNF) is the most frequently prescribed treatment; however, it is not universally accessible. In fact, in Brazil, many patients are only given the option of receiving nonbiological therapy. This approach prolongs the subsequent clinical relapse; however, this procedure could be implicated in the immune response and enhance disease severity. Our purpose was to assess the effects of different treatments on CD4+ T cells in a cohort of patients with Crohn’s disease compared with healthy individuals. To examine the immune status in a Brazilian cohort, we analyzed CD4+ T cells, activation status, cytokine production, and Treg cells in blood of Crohn’s patients. Patients that underwent biological therapy can recover the percentage of CD4+CD73+ T cells, decrease the CD4+ T cell activation/effector functions, and maintain the peripheral percentage of regulatory T cells. These results show that anti-TNF agents can improve CD4+ T cell subsets, thereby inducing Crohn’s patients to relapse and remission rates.http://dx.doi.org/10.1155/2022/1307159 |
| spellingShingle | Eliane Aparecida Rosseto-Welter Leticia D’argenio-Garcia Filipa Blasco Tavares Pereira Lopes Ana Eduarda Zulim Carvalho Fernando Flaquer Vanessa Severo-Lemos Claudia Concer Viero Nora Flavio Steinwurz Lucas Pires Garcia Oliveria Thiago Aloia Luiz Vicente Rizzo Cristóvão Luis Pitangueira Mangueira Karina Inacio Carvalho Biologic Agents in Crohn’s Patients Reduce CD4+ T Cells Activation and Are Inversely Related to Treg Cells Canadian Journal of Gastroenterology and Hepatology |
| title | Biologic Agents in Crohn’s Patients Reduce CD4+ T Cells Activation and Are Inversely Related to Treg Cells |
| title_full | Biologic Agents in Crohn’s Patients Reduce CD4+ T Cells Activation and Are Inversely Related to Treg Cells |
| title_fullStr | Biologic Agents in Crohn’s Patients Reduce CD4+ T Cells Activation and Are Inversely Related to Treg Cells |
| title_full_unstemmed | Biologic Agents in Crohn’s Patients Reduce CD4+ T Cells Activation and Are Inversely Related to Treg Cells |
| title_short | Biologic Agents in Crohn’s Patients Reduce CD4+ T Cells Activation and Are Inversely Related to Treg Cells |
| title_sort | biologic agents in crohn s patients reduce cd4 t cells activation and are inversely related to treg cells |
| url | http://dx.doi.org/10.1155/2022/1307159 |
| work_keys_str_mv | AT elianeaparecidarossetowelter biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT leticiadargeniogarcia biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT filipablascotavarespereiralopes biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT anaeduardazulimcarvalho biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT fernandoflaquer biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT vanessaseverolemos biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT claudiaconcervieronora biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT flaviosteinwurz biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT lucaspiresgarciaoliveria biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT thiagoaloia biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT luizvicenterizzo biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT cristovaoluispitangueiramangueira biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells AT karinainaciocarvalho biologicagentsincrohnspatientsreducecd4tcellsactivationandareinverselyrelatedtotregcells |