Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy
Background: We conducted this study to investigate adverse pregnancy outcomes of hepatitis B virus infection coexistng with intrahepatic cholestasis in pregnant women, along with identifying associated risk factors. Methods: We retrospectively collected study data from Beijing Youan Hospital in Chin...
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IMR Press
2024-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102036 |
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| author | Chong Zhang Hong Wei Zhiqiang Zhao Yunxia Zhu |
| author_facet | Chong Zhang Hong Wei Zhiqiang Zhao Yunxia Zhu |
| author_sort | Chong Zhang |
| collection | DOAJ |
| description | Background: We conducted this study to investigate adverse pregnancy outcomes of hepatitis B virus infection coexistng with intrahepatic cholestasis in pregnant women, along with identifying associated risk factors. Methods: We retrospectively collected study data from Beijing Youan Hospital in China spanning January 2014 to December 2021. The study included 220 patients, divided into two groups: Group I consisted of 110 patients with hepatitis B virus infection and intrahepatic cholestasis during pregnancy, while Group II comprised 110 patients with hepatitis B virus infection alone. Maternal demographics, laboratory values, obstetric complications, and adverse pregnancy outcomes were collected and analyzed between Groups I and II. To investigate the features of hepatitis B virus infection with intrahepatic cholestasis in pregnancy patients further, we also evaluated risk factors of adverse pregnancy outcomes in Group I. Results: Adverse pregnancy outcomes, including preterm birth (<37 weeks (w)), postpartum hemorrhage, meconium-stained amniotic fluid, neonatal asphyxia, neonate intensive care unit admission and small for gestational age rates were significantly increased for Group I compared with Group II (p < 0.05). In hepatitis B virus infection patients with intrahepatic cholestasis during pregnancy, elevated total serum bile acids independently correlated with six adverse pregnancy outcomes. Conclusions: Pregnant patients with both hepatitis B virus infection and intrahepatic cholestasis experienced a higher occurrence of adverse pregnancy outcomes compared to those with Hepatitis B virus infection alone. Total serum bile acids were an independent risk factor for adverse pregnancy outcomes in Hepatitis B virus infection with intrahepatic cholestasis during pregnancy. Clinical Trial Registration: The study was registered with https://classic.clinicaltrials.gov/ (no.: zx10201201). |
| format | Article |
| id | doaj-art-c016ba3cda2b4fc3a29bc8a18f199273 |
| institution | DOAJ |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-c016ba3cda2b4fc3a29bc8a18f1992732025-08-20T03:05:17ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-02-015123610.31083/j.ceog5102036S0390-6663(23)02197-8Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During PregnancyChong Zhang0Hong Wei1Zhiqiang Zhao2Yunxia Zhu3Departments of Obstetrics, Beijing Youan Hospital, Capital Medical University, 100069 Beijing, ChinaDepartments of Obstetrics, Beijing Youan Hospital, Capital Medical University, 100069 Beijing, ChinaDepartments of Obstetrics, Beijing Youan Hospital, Capital Medical University, 100069 Beijing, ChinaDepartments of Obstetrics, Beijing Youan Hospital, Capital Medical University, 100069 Beijing, ChinaBackground: We conducted this study to investigate adverse pregnancy outcomes of hepatitis B virus infection coexistng with intrahepatic cholestasis in pregnant women, along with identifying associated risk factors. Methods: We retrospectively collected study data from Beijing Youan Hospital in China spanning January 2014 to December 2021. The study included 220 patients, divided into two groups: Group I consisted of 110 patients with hepatitis B virus infection and intrahepatic cholestasis during pregnancy, while Group II comprised 110 patients with hepatitis B virus infection alone. Maternal demographics, laboratory values, obstetric complications, and adverse pregnancy outcomes were collected and analyzed between Groups I and II. To investigate the features of hepatitis B virus infection with intrahepatic cholestasis in pregnancy patients further, we also evaluated risk factors of adverse pregnancy outcomes in Group I. Results: Adverse pregnancy outcomes, including preterm birth (<37 weeks (w)), postpartum hemorrhage, meconium-stained amniotic fluid, neonatal asphyxia, neonate intensive care unit admission and small for gestational age rates were significantly increased for Group I compared with Group II (p < 0.05). In hepatitis B virus infection patients with intrahepatic cholestasis during pregnancy, elevated total serum bile acids independently correlated with six adverse pregnancy outcomes. Conclusions: Pregnant patients with both hepatitis B virus infection and intrahepatic cholestasis experienced a higher occurrence of adverse pregnancy outcomes compared to those with Hepatitis B virus infection alone. Total serum bile acids were an independent risk factor for adverse pregnancy outcomes in Hepatitis B virus infection with intrahepatic cholestasis during pregnancy. Clinical Trial Registration: The study was registered with https://classic.clinicaltrials.gov/ (no.: zx10201201).https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102036adverse pregnancy outcomeshepatitis b virus infectionintrahepatic cholestasis in pregnancyprognostic factorstotal serum bile acids |
| spellingShingle | Chong Zhang Hong Wei Zhiqiang Zhao Yunxia Zhu Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy Clinical and Experimental Obstetrics & Gynecology adverse pregnancy outcomes hepatitis b virus infection intrahepatic cholestasis in pregnancy prognostic factors total serum bile acids |
| title | Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy |
| title_full | Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy |
| title_fullStr | Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy |
| title_full_unstemmed | Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy |
| title_short | Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy |
| title_sort | adverse pregnancy outcomes and prognostic factors in hepatitis b virus patients with intrahepatic cholestasis during pregnancy |
| topic | adverse pregnancy outcomes hepatitis b virus infection intrahepatic cholestasis in pregnancy prognostic factors total serum bile acids |
| url | https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102036 |
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