Somatostatin and its receptors involvement in sevoflurane-induced neurotoxicity: a narrative review

Somatostatin and its receptors involvement in sevoflurane-induced neurotoxicity: a narrative review

Abstract As a widely used pediatric anesthetic, sevoflurane presents a paradoxical neurodevelopmental risk during vulnerable brain maturation periods. This review synthesizes emerging evidence on sevoflurane-induced developmental neurotoxicity, with a focus on somatostatin (SST)-SSTR4 signaling and...

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Main Authors: Yixuan Niu, Jinnan Xu, Yanyong Cheng, Linhong Zhong, Jing Wang, Yanan Jiang, Chen Wang, Zhengjie Miao, Fan Wang, Chuanyu Qi, Tiannan Chen, Yi Gao, Hong Jiang, Jia Yan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Anesthesiology
Subjects:
Sevoflurane
Developmental neurotoxicity
SST
SSTR4
Synaptic plasticity
Online Access:https://doi.org/10.1186/s12871-025-03242-4
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