Detection of breast cancer lesions using APT weighted MRI: a systematic review
Abstract Amide proton transfer (APT) is a novel magnetic resonance imaging (MRI) technique that has shown promising ability to study cancers. This paper systematically reviewed the literature on the use of APT MRI in the prognosis of breast cancer. A literature search was conducted on Pubmed and Emb...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06153-7 |
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| author | Ryan C. Lee Montek Singh Boparai Tim Q. Duong |
| author_facet | Ryan C. Lee Montek Singh Boparai Tim Q. Duong |
| author_sort | Ryan C. Lee |
| collection | DOAJ |
| description | Abstract Amide proton transfer (APT) is a novel magnetic resonance imaging (MRI) technique that has shown promising ability to study cancers. This paper systematically reviewed the literature on the use of APT MRI in the prognosis of breast cancer. A literature search was conducted on Pubmed and Embase and a total of 14 articles comprising 775 patients were included in the review. APT MRI had the ability to distinguish between benign and malignant lesions with an AUC as high as 0.959. There is a positive correlation between APT signal intensity and tumor grade/stage as well as Ki-67, whereas no correlation was found with ER/PR/Her-2 receptor status. There was a greater decrease in APT signal intensity after neoadjuvant chemotherapy (NAC) in responders compared to non-responders, suggesting that APT MRI may serve as a valuable supplemental tool in the early identification of chemotherapy response. APT has the potential to complement with other imaging methods in the diagnosis, prognosis, treatment monitoring, and management of breast cancer. Additional studies and standardization of APT acquisition methods are needed. |
| format | Article |
| id | doaj-art-c00815676e2c459aaac2d62b3e83fe28 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-c00815676e2c459aaac2d62b3e83fe282025-02-02T12:40:25ZengBMCJournal of Translational Medicine1479-58762025-01-012311910.1186/s12967-025-06153-7Detection of breast cancer lesions using APT weighted MRI: a systematic reviewRyan C. Lee0Montek Singh Boparai1Tim Q. Duong2Department of Radiology, Montefiore Medical Center and Albert Einstein College of MedicineDepartment of Radiology, Montefiore Medical Center and Albert Einstein College of MedicineDepartment of Radiology, Montefiore Medical Center and Albert Einstein College of MedicineAbstract Amide proton transfer (APT) is a novel magnetic resonance imaging (MRI) technique that has shown promising ability to study cancers. This paper systematically reviewed the literature on the use of APT MRI in the prognosis of breast cancer. A literature search was conducted on Pubmed and Embase and a total of 14 articles comprising 775 patients were included in the review. APT MRI had the ability to distinguish between benign and malignant lesions with an AUC as high as 0.959. There is a positive correlation between APT signal intensity and tumor grade/stage as well as Ki-67, whereas no correlation was found with ER/PR/Her-2 receptor status. There was a greater decrease in APT signal intensity after neoadjuvant chemotherapy (NAC) in responders compared to non-responders, suggesting that APT MRI may serve as a valuable supplemental tool in the early identification of chemotherapy response. APT has the potential to complement with other imaging methods in the diagnosis, prognosis, treatment monitoring, and management of breast cancer. Additional studies and standardization of APT acquisition methods are needed.https://doi.org/10.1186/s12967-025-06153-7Breast cancerAmide Proton transferChemical exchange saturation transferMRI |
| spellingShingle | Ryan C. Lee Montek Singh Boparai Tim Q. Duong Detection of breast cancer lesions using APT weighted MRI: a systematic review Journal of Translational Medicine Breast cancer Amide Proton transfer Chemical exchange saturation transfer MRI |
| title | Detection of breast cancer lesions using APT weighted MRI: a systematic review |
| title_full | Detection of breast cancer lesions using APT weighted MRI: a systematic review |
| title_fullStr | Detection of breast cancer lesions using APT weighted MRI: a systematic review |
| title_full_unstemmed | Detection of breast cancer lesions using APT weighted MRI: a systematic review |
| title_short | Detection of breast cancer lesions using APT weighted MRI: a systematic review |
| title_sort | detection of breast cancer lesions using apt weighted mri a systematic review |
| topic | Breast cancer Amide Proton transfer Chemical exchange saturation transfer MRI |
| url | https://doi.org/10.1186/s12967-025-06153-7 |
| work_keys_str_mv | AT ryanclee detectionofbreastcancerlesionsusingaptweightedmriasystematicreview AT monteksinghboparai detectionofbreastcancerlesionsusingaptweightedmriasystematicreview AT timqduong detectionofbreastcancerlesionsusingaptweightedmriasystematicreview |