Blastocyst complementation-based rat-derived heart generation reveals cardiac anomaly barriers to interspecies chimera development

Blastocyst complementation-based rat-derived heart generation reveals cardiac anomaly barriers to interspecies chimera development

Summary: The use of pluripotent stem cells (PSCs) to generate functional organs via blastocyst complementation is a cutting-edge strategy in regenerative medicine. However, existing models that use this method for heart generation do not meet expectations owing to the complexity of heart development...

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Bibliographic Details
Main Authors: Shunsuke Yuri, Norie Arisawa, Kohei Kitamuro, Ayako Isotani
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Health sciences
cardiovascular medicine
biological sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224026397
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