Association between types of surgery and cancer-specific death in patients with early differentiated thyroid carcinoma: a real-world study
ObjectiveTo explore the association between types of surgery and outcomes in patients with early differentiated thyroid carcinoma (DTC) by a real-world study.MethodsAll the data were from Surveillance, Epidemiology, and End Results (SEER). Types of surgery included Surgery 1 (lobectomy, isthmectomy,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1540705/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849318291377487872 |
|---|---|
| author | Jia-wei Yu Rui Pang Bo Liu Liang Zhang Ling-yu Kong |
| author_facet | Jia-wei Yu Rui Pang Bo Liu Liang Zhang Ling-yu Kong |
| author_sort | Jia-wei Yu |
| collection | DOAJ |
| description | ObjectiveTo explore the association between types of surgery and outcomes in patients with early differentiated thyroid carcinoma (DTC) by a real-world study.MethodsAll the data were from Surveillance, Epidemiology, and End Results (SEER). Types of surgery included Surgery 1 (lobectomy, isthmectomy, or removal of less than a lobe), Surgery 2 (subtotal or near total thyroidectomy, or removal of a lobe and partial removal of the contralateral lobe), and Surgery 3 (total thyroidectomy). The association between types of surgery and DTC or other causes of death was explored by a competitive risk model and subgroup analysis. We also used the machine learning algorithm to evaluate the importance of types of surgery on long-term outcomes.ResultsA total of 7,230 patients were enrolled, of whom 1,512, 249, and 5,469 patients received Surgery 1, Surgery 2, and Surgery 3, respectively. The long-term outcomes among the three groups differed significantly (P < 0.001). Competitive risk analysis showed that types of surgery were significantly associated with DTC-related death (P=0.005), other causes death (P<0.001) in the crude model, and three adjusted models further indicated their independent association (all adjusted P<0.05). Specifically, Surgery 2 was associated with the highest DTC-related death. However, when the death of other causes was refined, types of surgery were only related to DTC-related death (all adjusted P<0.05). The importance analysis suggested that the impact of surgical type on long-term outcomes may be underrecognized.ConclusionsThe types of surgery were significantly related to the DTC-related death of patients, and it deserved attention. Additionally, Surgery 2 was associated with higher DTC-related death. |
| format | Article |
| id | doaj-art-bfff2ea43ab24fcaa98f4d90e71d8921 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-bfff2ea43ab24fcaa98f4d90e71d89212025-08-20T03:50:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.15407051540705Association between types of surgery and cancer-specific death in patients with early differentiated thyroid carcinoma: a real-world studyJia-wei YuRui PangBo LiuLiang ZhangLing-yu KongObjectiveTo explore the association between types of surgery and outcomes in patients with early differentiated thyroid carcinoma (DTC) by a real-world study.MethodsAll the data were from Surveillance, Epidemiology, and End Results (SEER). Types of surgery included Surgery 1 (lobectomy, isthmectomy, or removal of less than a lobe), Surgery 2 (subtotal or near total thyroidectomy, or removal of a lobe and partial removal of the contralateral lobe), and Surgery 3 (total thyroidectomy). The association between types of surgery and DTC or other causes of death was explored by a competitive risk model and subgroup analysis. We also used the machine learning algorithm to evaluate the importance of types of surgery on long-term outcomes.ResultsA total of 7,230 patients were enrolled, of whom 1,512, 249, and 5,469 patients received Surgery 1, Surgery 2, and Surgery 3, respectively. The long-term outcomes among the three groups differed significantly (P < 0.001). Competitive risk analysis showed that types of surgery were significantly associated with DTC-related death (P=0.005), other causes death (P<0.001) in the crude model, and three adjusted models further indicated their independent association (all adjusted P<0.05). Specifically, Surgery 2 was associated with the highest DTC-related death. However, when the death of other causes was refined, types of surgery were only related to DTC-related death (all adjusted P<0.05). The importance analysis suggested that the impact of surgical type on long-term outcomes may be underrecognized.ConclusionsThe types of surgery were significantly related to the DTC-related death of patients, and it deserved attention. Additionally, Surgery 2 was associated with higher DTC-related death.https://www.frontiersin.org/articles/10.3389/fonc.2025.1540705/fulldifferentiated thyroid carcinomasurgeryoutcomeSEERcompetitive risk model |
| spellingShingle | Jia-wei Yu Rui Pang Bo Liu Liang Zhang Ling-yu Kong Association between types of surgery and cancer-specific death in patients with early differentiated thyroid carcinoma: a real-world study Frontiers in Oncology differentiated thyroid carcinoma surgery outcome SEER competitive risk model |
| title | Association between types of surgery and cancer-specific death in patients with early differentiated thyroid carcinoma: a real-world study |
| title_full | Association between types of surgery and cancer-specific death in patients with early differentiated thyroid carcinoma: a real-world study |
| title_fullStr | Association between types of surgery and cancer-specific death in patients with early differentiated thyroid carcinoma: a real-world study |
| title_full_unstemmed | Association between types of surgery and cancer-specific death in patients with early differentiated thyroid carcinoma: a real-world study |
| title_short | Association between types of surgery and cancer-specific death in patients with early differentiated thyroid carcinoma: a real-world study |
| title_sort | association between types of surgery and cancer specific death in patients with early differentiated thyroid carcinoma a real world study |
| topic | differentiated thyroid carcinoma surgery outcome SEER competitive risk model |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1540705/full |
| work_keys_str_mv | AT jiaweiyu associationbetweentypesofsurgeryandcancerspecificdeathinpatientswithearlydifferentiatedthyroidcarcinomaarealworldstudy AT ruipang associationbetweentypesofsurgeryandcancerspecificdeathinpatientswithearlydifferentiatedthyroidcarcinomaarealworldstudy AT boliu associationbetweentypesofsurgeryandcancerspecificdeathinpatientswithearlydifferentiatedthyroidcarcinomaarealworldstudy AT liangzhang associationbetweentypesofsurgeryandcancerspecificdeathinpatientswithearlydifferentiatedthyroidcarcinomaarealworldstudy AT lingyukong associationbetweentypesofsurgeryandcancerspecificdeathinpatientswithearlydifferentiatedthyroidcarcinomaarealworldstudy |