Age-Related White Matter Changes
Age-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and are related to age and vascular risk factors. Most recent studies have shown that WMC are associated with a host of poor outcomes, including cognitive impairment, dementia, urinary inco...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/617927 |
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| _version_ | 1832550653152460800 |
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| author | Yun Yun Xiong Vincent Mok |
| author_facet | Yun Yun Xiong Vincent Mok |
| author_sort | Yun Yun Xiong |
| collection | DOAJ |
| description | Age-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and are related to age and vascular risk factors. Most recent studies have shown that WMC are associated with a host of poor outcomes, including cognitive impairment, dementia, urinary incontinence, gait disturbances, depression, and increased risk of stroke and death. Although the clinical relevance of WMC has been extensively studied, to date, only very few clinical trials have evaluated potential symptomatic or preventive treatments for WMC. In this paper, we reviewed the current understanding in the pathophysiology, epidemiology, clinical importance, chemical biomarkers, and treatments of age-related WMC. |
| format | Article |
| id | doaj-art-bffb66fc5b7e4c44b097c336ffb855c2 |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-bffb66fc5b7e4c44b097c336ffb855c22025-02-03T06:06:20ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/617927617927Age-Related White Matter ChangesYun Yun Xiong0Vincent Mok1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Shatin 999077, Hong KongDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Shatin 999077, Hong KongAge-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and are related to age and vascular risk factors. Most recent studies have shown that WMC are associated with a host of poor outcomes, including cognitive impairment, dementia, urinary incontinence, gait disturbances, depression, and increased risk of stroke and death. Although the clinical relevance of WMC has been extensively studied, to date, only very few clinical trials have evaluated potential symptomatic or preventive treatments for WMC. In this paper, we reviewed the current understanding in the pathophysiology, epidemiology, clinical importance, chemical biomarkers, and treatments of age-related WMC.http://dx.doi.org/10.4061/2011/617927 |
| spellingShingle | Yun Yun Xiong Vincent Mok Age-Related White Matter Changes Journal of Aging Research |
| title | Age-Related White Matter Changes |
| title_full | Age-Related White Matter Changes |
| title_fullStr | Age-Related White Matter Changes |
| title_full_unstemmed | Age-Related White Matter Changes |
| title_short | Age-Related White Matter Changes |
| title_sort | age related white matter changes |
| url | http://dx.doi.org/10.4061/2011/617927 |
| work_keys_str_mv | AT yunyunxiong agerelatedwhitematterchanges AT vincentmok agerelatedwhitematterchanges |