Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis
Aim. Cavernous hemangioma-like Kaposi sarcoma is a rare morphologic type of Kaposi sarcoma. So far there are no cases in the literature defining the histological features of this morphologic spectrum in detail. In this study we presented two classical-type cutaneous Kaposi sarcoma cases with histolo...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/959812 |
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| author | Nilüfer Onak Kandemir Figen Barut Banu Doğan Gün Nilgün Solak Tekin Sevinç Hallaç Keser Şükrü Oğuz Özdamar |
| author_facet | Nilüfer Onak Kandemir Figen Barut Banu Doğan Gün Nilgün Solak Tekin Sevinç Hallaç Keser Şükrü Oğuz Özdamar |
| author_sort | Nilüfer Onak Kandemir |
| collection | DOAJ |
| description | Aim. Cavernous hemangioma-like Kaposi sarcoma is a rare morphologic type of Kaposi sarcoma. So far there are no cases in the literature defining the histological features of this morphologic spectrum in detail. In this study we presented two classical-type cutaneous Kaposi sarcoma cases with histologic findings resembling cavernous hemangioma in company with clinical and histopathological data. Cases. One hundred and eighty-five classical-type cutaneous Kaposi sarcoma lesions in 79 patients were assessed retrospectively in terms of histopathological features. Findings of two cases showing features of cavernous hemangioma-like Kaposi sarcoma whose clinical data could be accessed were presented in accompany with the literature data. Both cases were detected to have bluish-purple, protruded, irregularly bordered cutaneous lesions. Histopathological examination revealed a lesion formed by cavernous hemangioma-like vascular structures organized in a lobular pattern that became dilated and filled with blood. Typical histological findings of early-stage KS, consisting of mononuclear inflammation, extravasated erythrocytes, and a few immature vascular structures in superficial dermis, were observed. All cases were serologically HIV-1 negative. A positive reaction with HHV-8, CD31, CD34, and D2-40 monoclonal antibodies was identified at both cavernous hemangioma-like areas and in immature vascular structures. Results. Cavernous hemangioma-like Kaposi sarcoma is a rare Kaposi sarcoma variant presenting with diagnostic challenges, that may be confused with hemangioma. As characteristic morphological features may not be observed in every case, it is important for diagnostic purposes to show immunohistochemical HHV-8 positivity in this variant. |
| format | Article |
| id | doaj-art-bff80e550c9442acaad49579504c1ea5 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-bff80e550c9442acaad49579504c1ea52025-02-03T01:23:47ZengWileyCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/959812959812Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential DiagnosisNilüfer Onak Kandemir0Figen Barut1Banu Doğan Gün2Nilgün Solak Tekin3Sevinç Hallaç Keser4Şükrü Oğuz Özdamar5Department of Pathology, Faculty of Medicine, Bülent Ecevit University, 67100 Zonguldak, TurkeyDepartment of Pathology, Faculty of Medicine, Bülent Ecevit University, 67100 Zonguldak, TurkeyDepartment of Pathology, Faculty of Medicine, Bülent Ecevit University, 67100 Zonguldak, TurkeyDepartment of Dermatology, Faculty of Medicine, Bülent Ecevit University, 67100 Zonguldak, TurkeyDepartment of Pathology, Dr. Lütfi Kırdar Training and Research Hospital, Istanbul, TurkeyDepartment of Pathology, Faculty of Medicine, Bülent Ecevit University, 67100 Zonguldak, TurkeyAim. Cavernous hemangioma-like Kaposi sarcoma is a rare morphologic type of Kaposi sarcoma. So far there are no cases in the literature defining the histological features of this morphologic spectrum in detail. In this study we presented two classical-type cutaneous Kaposi sarcoma cases with histologic findings resembling cavernous hemangioma in company with clinical and histopathological data. Cases. One hundred and eighty-five classical-type cutaneous Kaposi sarcoma lesions in 79 patients were assessed retrospectively in terms of histopathological features. Findings of two cases showing features of cavernous hemangioma-like Kaposi sarcoma whose clinical data could be accessed were presented in accompany with the literature data. Both cases were detected to have bluish-purple, protruded, irregularly bordered cutaneous lesions. Histopathological examination revealed a lesion formed by cavernous hemangioma-like vascular structures organized in a lobular pattern that became dilated and filled with blood. Typical histological findings of early-stage KS, consisting of mononuclear inflammation, extravasated erythrocytes, and a few immature vascular structures in superficial dermis, were observed. All cases were serologically HIV-1 negative. A positive reaction with HHV-8, CD31, CD34, and D2-40 monoclonal antibodies was identified at both cavernous hemangioma-like areas and in immature vascular structures. Results. Cavernous hemangioma-like Kaposi sarcoma is a rare Kaposi sarcoma variant presenting with diagnostic challenges, that may be confused with hemangioma. As characteristic morphological features may not be observed in every case, it is important for diagnostic purposes to show immunohistochemical HHV-8 positivity in this variant.http://dx.doi.org/10.1155/2013/959812 |
| spellingShingle | Nilüfer Onak Kandemir Figen Barut Banu Doğan Gün Nilgün Solak Tekin Sevinç Hallaç Keser Şükrü Oğuz Özdamar Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis Case Reports in Medicine |
| title | Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis |
| title_full | Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis |
| title_fullStr | Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis |
| title_full_unstemmed | Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis |
| title_short | Cavernous Hemangioma-Like Kaposi Sarcoma: Histomorphologic Features and Differential Diagnosis |
| title_sort | cavernous hemangioma like kaposi sarcoma histomorphologic features and differential diagnosis |
| url | http://dx.doi.org/10.1155/2013/959812 |
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