Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention?
Inflammation triggered by oxidative stress is the cause of much, perhaps even most, chronic human disease including human aging. The oxidative stress originates mainly in mitochondria from reactive oxygen and reactive nitrogen species (ROS/RNS) and can be identified in most of the key steps in the p...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2011/514623 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554974299553792 |
|---|---|
| author | Fredric J. Pashkow |
| author_facet | Fredric J. Pashkow |
| author_sort | Fredric J. Pashkow |
| collection | DOAJ |
| description | Inflammation triggered by oxidative stress is the cause of much, perhaps even most, chronic human disease including human aging. The oxidative stress originates mainly in mitochondria from reactive oxygen and reactive nitrogen species (ROS/RNS) and can be identified in most of the key steps in the pathophysiology of atherosclerosis and the consequential clinical manifestations of cardiovascular disease. In addition to the formation of atherosclerosis, it involves lipid metabolism, plaque rupture, thrombosis, myocardial injury, apoptosis, fibrosis and failure. The recognition of the critical importance of oxidative stress has led to the enthusiastic use of antioxidants in the treatment and prevention of heart disease, but the results of prospective, randomized clinical trials have been overall disappointing. Can this contradiction be explained and what are its implications for the discovery/development of future antioxidant therapeutics? |
| format | Article |
| id | doaj-art-bff6119ac539489ba550b8fcd6aa9d51 |
| institution | Kabale University |
| issn | 2042-0099 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-bff6119ac539489ba550b8fcd6aa9d512025-02-03T05:49:57ZengWileyInternational Journal of Inflammation2042-00992011-01-01201110.4061/2011/514623514623Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention?Fredric J. Pashkow0John A. Burns School of Medicine, University of Hawai‘i, Honolulu, HI, USAInflammation triggered by oxidative stress is the cause of much, perhaps even most, chronic human disease including human aging. The oxidative stress originates mainly in mitochondria from reactive oxygen and reactive nitrogen species (ROS/RNS) and can be identified in most of the key steps in the pathophysiology of atherosclerosis and the consequential clinical manifestations of cardiovascular disease. In addition to the formation of atherosclerosis, it involves lipid metabolism, plaque rupture, thrombosis, myocardial injury, apoptosis, fibrosis and failure. The recognition of the critical importance of oxidative stress has led to the enthusiastic use of antioxidants in the treatment and prevention of heart disease, but the results of prospective, randomized clinical trials have been overall disappointing. Can this contradiction be explained and what are its implications for the discovery/development of future antioxidant therapeutics?http://dx.doi.org/10.4061/2011/514623 |
| spellingShingle | Fredric J. Pashkow Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? International Journal of Inflammation |
| title | Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? |
| title_full | Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? |
| title_fullStr | Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? |
| title_full_unstemmed | Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? |
| title_short | Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention? |
| title_sort | oxidative stress and inflammation in heart disease do antioxidants have a role in treatment and or prevention |
| url | http://dx.doi.org/10.4061/2011/514623 |
| work_keys_str_mv | AT fredricjpashkow oxidativestressandinflammationinheartdiseasedoantioxidantshavearoleintreatmentandorprevention |