Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study
Although epidemiological evidence has linked maternal exposure to air pollution with adverse birth outcomes, the association between exposure to fine particulate matter (PM2.5) and the risk of total birth defects in highly polluted developing regions remains limited. The objective of this study was...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324014842 |
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| author | Shihan Zhen Na Li Yan Li Qian Li Lu Zheng Zhouxin Yin Yan Dou Shuqi Wu Yilin Liu Xiaoyan Zhang Xinyue Yang Ye Wang Wenxiu Ge Xiaoyu Gao Jing Yang Fengchao Liang Jiajin Hu Ying Zhao |
| author_facet | Shihan Zhen Na Li Yan Li Qian Li Lu Zheng Zhouxin Yin Yan Dou Shuqi Wu Yilin Liu Xiaoyan Zhang Xinyue Yang Ye Wang Wenxiu Ge Xiaoyu Gao Jing Yang Fengchao Liang Jiajin Hu Ying Zhao |
| author_sort | Shihan Zhen |
| collection | DOAJ |
| description | Although epidemiological evidence has linked maternal exposure to air pollution with adverse birth outcomes, the association between exposure to fine particulate matter (PM2.5) and the risk of total birth defects in highly polluted developing regions remains limited. The objective of this study was to assess the relationship between maternal exposure to PM2.5 before and during pregnancy and the occurrence of birth defects. This study included 16,080 births with birth defects and 567,483 controls born between 2014 and 2019 in 14 cities in Liaoning Province, China. The assessment of exposure was conducted using satellite-based PM2.5 data at a spatial resolution of 1 km. Participants were classified into four subgroups based on their exposure to PM2.5 before and during pregnancy. The association between maternal exposure to PM2.5, and the risk of birth defects, was estimated using logistic regression models. For each 10 μg/m³ increase in PM2.5, the odds ratios of birth defects were 1.68 (95% CI: 1.65, 1.70) and 2.41 (95% CI: 2.36, 2.45) during the preconception period and pregnancy, respectively. We observed a J-shaped association between maternal PM2.5 exposure during both the preconception period and pregnancy and the risk of total birth defects. Mothers exposed to elevated levels of PM2.5 during both the preconception period and pregnancy exhibited the highest risk of total birth defects (odds ratio: 4.43, 95% CI: 4.17, 4.71). Our findings illustrated that maternal exposure to PM2.5 before and during pregnancy was associated with increased risks of birth defects and underscored the potential health benefits of reducing air pollution exposure during the preconception period and pregnancy. |
| format | Article |
| id | doaj-art-bfe6dcd133534fbeb4c407ab72f2d3e6 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-bfe6dcd133534fbeb4c407ab72f2d3e62025-01-23T05:25:27ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117408Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based studyShihan Zhen0Na Li1Yan Li2Qian Li3Lu Zheng4Zhouxin Yin5Yan Dou6Shuqi Wu7Yilin Liu8Xiaoyan Zhang9Xinyue Yang10Ye Wang11Wenxiu Ge12Xiaoyu Gao13Jing Yang14Fengchao Liang15Jiajin Hu16Ying Zhao17School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, China Medical University, Shenyang 110004, ChinaLiaoning Provincial Hospital for Women and Children, Shenyang 110005, ChinaSchool of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen 518055, ChinaResearch Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang 110004, China; Health Sciences Institute, China Medical University, Shenyang 110122, ChinaSchool of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Epidemiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaResearch Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang 110004, China; Health Sciences Institute, China Medical University, Shenyang 110122, ChinaDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, China Medical University, Shenyang 110004, China; Research Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang 110004, ChinaResearch Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang 110004, China; Health Sciences Institute, China Medical University, Shenyang 110122, ChinaResearch Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang 110004, China; Health Sciences Institute, China Medical University, Shenyang 110122, ChinaResearch Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang 110004, China; Health Sciences Institute, China Medical University, Shenyang 110122, ChinaResearch Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang 110004, China; Health Sciences Institute, China Medical University, Shenyang 110122, ChinaResearch Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang 110004, China; Health Sciences Institute, China Medical University, Shenyang 110122, ChinaResearch Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang 110004, China; Health Sciences Institute, China Medical University, Shenyang 110122, ChinaSchool of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen 518055, China; Corresponding authors.Research Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang 110004, China; Health Sciences Institute, China Medical University, Shenyang 110122, China; Corresponding authors.Liaoning Provincial Hospital for Women and Children, Shenyang 110005, China; Corresponding author at: Health Sciences Institute, China Medical University, Shenyang 110122, China.Although epidemiological evidence has linked maternal exposure to air pollution with adverse birth outcomes, the association between exposure to fine particulate matter (PM2.5) and the risk of total birth defects in highly polluted developing regions remains limited. The objective of this study was to assess the relationship between maternal exposure to PM2.5 before and during pregnancy and the occurrence of birth defects. This study included 16,080 births with birth defects and 567,483 controls born between 2014 and 2019 in 14 cities in Liaoning Province, China. The assessment of exposure was conducted using satellite-based PM2.5 data at a spatial resolution of 1 km. Participants were classified into four subgroups based on their exposure to PM2.5 before and during pregnancy. The association between maternal exposure to PM2.5, and the risk of birth defects, was estimated using logistic regression models. For each 10 μg/m³ increase in PM2.5, the odds ratios of birth defects were 1.68 (95% CI: 1.65, 1.70) and 2.41 (95% CI: 2.36, 2.45) during the preconception period and pregnancy, respectively. We observed a J-shaped association between maternal PM2.5 exposure during both the preconception period and pregnancy and the risk of total birth defects. Mothers exposed to elevated levels of PM2.5 during both the preconception period and pregnancy exhibited the highest risk of total birth defects (odds ratio: 4.43, 95% CI: 4.17, 4.71). Our findings illustrated that maternal exposure to PM2.5 before and during pregnancy was associated with increased risks of birth defects and underscored the potential health benefits of reducing air pollution exposure during the preconception period and pregnancy.http://www.sciencedirect.com/science/article/pii/S0147651324014842Birth defectCongenitalEnvironmentPregnancyFine particulate matter |
| spellingShingle | Shihan Zhen Na Li Yan Li Qian Li Lu Zheng Zhouxin Yin Yan Dou Shuqi Wu Yilin Liu Xiaoyan Zhang Xinyue Yang Ye Wang Wenxiu Ge Xiaoyu Gao Jing Yang Fengchao Liang Jiajin Hu Ying Zhao Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study Ecotoxicology and Environmental Safety Birth defect Congenital Environment Pregnancy Fine particulate matter |
| title | Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study |
| title_full | Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study |
| title_fullStr | Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study |
| title_full_unstemmed | Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study |
| title_short | Maternal exposure to fine particulate matter before and during pregnancy, and the risk of birth defects: A population-based study |
| title_sort | maternal exposure to fine particulate matter before and during pregnancy and the risk of birth defects a population based study |
| topic | Birth defect Congenital Environment Pregnancy Fine particulate matter |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324014842 |
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