GGT and GSH-triggered nanoplatform for efficient gambogic acid delivery and tumor penetration in triple-negative breast cancer

GGT and GSH-triggered nanoplatform for efficient gambogic acid delivery and tumor penetration in triple-negative breast cancer

Emerging nanodrug delivery strategies seek to overcome tumor heterogeneity and enhance drug penetration in the dense matrix of solid tumors. This study presents a dual-responsive nanoplatform, poly(lactic-co-glycolic acid)-disulfide-polyethylene glycol-glutamate (PLGA-SS-PEG-Glu) loaded with Gambogi...

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Bibliographic Details
Main Authors:	Su Li, Qinghua Wang, Chen Su, Zhen Jia, Guoshuang Shen, Mengting Da, Rui Yang, Jiuda Zhao, Daozhen Chen
Format:	Article
Language:	English
Published:	Elsevier 2025-08-01
Series:	Materials Today Bio
Subjects:	γ-glutamyltranspeptidase Triple-negative breast cancer Dual-responsive Charge-reversal Cancer therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590006425006003
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