Safety and Efficacy of Ephedrine Alkaloids-Free Ephedra Herb Extract (EFE) for Mild COVID-19: A Double-Blind, Placebo-Controlled, Randomized Comparative Trial

Safety and Efficacy of Ephedrine Alkaloids-Free Ephedra Herb Extract (EFE) for Mild COVID-19: A Double-Blind, Placebo-Controlled, Randomized Comparative Trial

Several Ephedra Herb-containing Kampo medicines are common initial treatments for various infections; however, the ephedrine alkaloids in Ephedra Herb can cause side effects by stimulating adrenergic receptors. Accordingly, an ephedrine alkaloids-free Ephedra Herb Extract (EFE) has been developed. T...

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Main Authors: Hiroshi Odaguchi, Sumiko Hyuga, Mariko Sekine, Hirofumi Michimae, Masashi Hyuga, Nahoko Uchiyama, Masashi Uema, Yuji Kumagai, Yusuke Suzuki, Shigeki Nabeshima, Norio Omagari, Yohei Doi, Kunihiro Yamaoka, Koji Miyazaki, Susumu Fuji, Yoshihiro Umezawa, Shiho Kodera, Hirotaka Nagashima, Wataru Hirose, Yukihiro Goda
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Microorganisms
Subjects:
SARS-CoV-2
COVID-19
EFE
DB-RCT
Kampo medicine
crude drug
Online Access:https://www.mdpi.com/2076-2607/13/3/641
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