Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus CNS infection

Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus CNS infection

Abstract Background Herpes Simplex Virus 1 (HSV-1) is a neurotropic virus causing encephalitis and post-infectious complications. Infections can induce a range of acute, subacute, and progressing brain disease, and in recent years it has emerged that immune responses are involved in the pathogenesis...

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Main Authors: Xiangning Ding, Xin Lai, Ida H. Klaestrup, Sara R. N. Jensen, Morten M. Nielsen, Kasper Thorsen, Marina Romero-Ramos, Yonglun Luo, Lin Lin, Line S. Reinert, Søren R. Paludan
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Neuroinflammation
Subjects:
Viral brain infection
Infection-induced brain inflammation
Single-cell RNA sequencing
Online Access:https://doi.org/10.1186/s12974-025-03471-x
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