The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection
Background. The systemic immune-inflammation index (SII) has an important role in predicting survival in some solid tumors. However, little information is available concerning the change of the SII (∆SII) in colorectal cancer (CRC) after curative resection. This study was designed to evaluate the ro...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/4105809 |
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| author | Qingqing Chen Haohao Wu Xinwei Guo Ke Gu Wenjie Wang Xiaochen Chen Shengjun Ji Hui Yang Jiahao Zhu |
| author_facet | Qingqing Chen Haohao Wu Xinwei Guo Ke Gu Wenjie Wang Xiaochen Chen Shengjun Ji Hui Yang Jiahao Zhu |
| author_sort | Qingqing Chen |
| collection | DOAJ |
| description | Background. The systemic immune-inflammation index (SII) has an important role in predicting survival in some solid tumors. However, little information is available concerning the change of the SII (∆SII) in colorectal cancer (CRC) after curative resection. This study was designed to evaluate the role of ∆SII in CRC patients who received surgery. Methods. A total 206 patients were enrolled in this study. Clinicopathologic characteristics and survival were assessed. The relationships between overall survival (OS), disease-free survival (DFS), and ∆SII were analyzed with both univariate Kaplan-Meier and multivariate Cox regression methods. Results. Based on the patient data, the receiver operating characteristic (ROC) optimal cutoff value of ∆SII was 127.7 for OS prediction. The 3-year and 5-year OS rates, respectively, were 60.4% and 36.7% in the high-∆SII group (>127.7) and 87.6% and 79.8% in the low-∆SII group (≤127.7). The 3-year and 5-year DFS rates, respectively, were 54.1% and 34.1% in the high-∆SII group and 80.3% and 78.5% in the low-∆SII group. In the univariate analysis, smoking, pathological stages III-IV, high-middle degree of differentiation, lymphatic invasion, vascular invasion, and the high-ΔSII group were associated with poor OS. Adjuvant therapy, pathological stages III-IV, vascular invasion, and ΔSII were able to predict DFS. Multivariate analysis revealed that pathological stages III-IV (HR=0.442, 95% CI=0.236-0.827, p=0.011), vascular invasion (HR=2.182, 95% CI=1.243-3.829, p=0.007), and the high-ΔSII group (HR=4.301, 95% CI=2.517-7.350, p<0.001) were independent predictors for OS. Adjuvant therapy (HR=0.415, 95% CI=0.250-0.687, p=0.001), vascular invasion (HR=3.305, 95% CI=1.944-5.620, p<0.001), and the high-ΔSII group (HR=4.924, 95% CI=2.992-8.102, p<0.001) were significant prognostic factors for DFS. Conclusions. The present study demonstrated that ∆SII was associated with the clinical outcome in CRC patients undergoing curative resection, supporting the role of ∆SII as a prognostic biomarker. |
| format | Article |
| id | doaj-art-bfd3a3ce68334f24858e24c1c0e55def |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | Mediators of Inflammation |
| spelling | doaj-art-bfd3a3ce68334f24858e24c1c0e55def2025-02-03T05:57:51ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/41058094105809The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative ResectionQingqing Chen0Haohao Wu1Xinwei Guo2Ke Gu3Wenjie Wang4Xiaochen Chen5Shengjun Ji6Hui Yang7Jiahao Zhu8Department of Radiotherapy & Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, ChinaDepartment of Radiotherapy, The Yancheng No. 1 People’s Hospital, Yancheng, ChinaDepartment of Oncology, Affiliated Taixing People’s Hospital of Yangzhou University, Taixing, ChinaDepartment of Radiotherapy & Oncology, Affiliated Hospital of Jiangnan University, Wuxi, ChinaDepartment of Radiotherapy & Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, ChinaDepartment of Radiotherapy & Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, ChinaDepartment of Radiotherapy & Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, ChinaDepartment of Radiotherapy & Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, ChinaDepartment of Radiotherapy & Oncology, Affiliated Hospital of Jiangnan University, Wuxi, ChinaBackground. The systemic immune-inflammation index (SII) has an important role in predicting survival in some solid tumors. However, little information is available concerning the change of the SII (∆SII) in colorectal cancer (CRC) after curative resection. This study was designed to evaluate the role of ∆SII in CRC patients who received surgery. Methods. A total 206 patients were enrolled in this study. Clinicopathologic characteristics and survival were assessed. The relationships between overall survival (OS), disease-free survival (DFS), and ∆SII were analyzed with both univariate Kaplan-Meier and multivariate Cox regression methods. Results. Based on the patient data, the receiver operating characteristic (ROC) optimal cutoff value of ∆SII was 127.7 for OS prediction. The 3-year and 5-year OS rates, respectively, were 60.4% and 36.7% in the high-∆SII group (>127.7) and 87.6% and 79.8% in the low-∆SII group (≤127.7). The 3-year and 5-year DFS rates, respectively, were 54.1% and 34.1% in the high-∆SII group and 80.3% and 78.5% in the low-∆SII group. In the univariate analysis, smoking, pathological stages III-IV, high-middle degree of differentiation, lymphatic invasion, vascular invasion, and the high-ΔSII group were associated with poor OS. Adjuvant therapy, pathological stages III-IV, vascular invasion, and ΔSII were able to predict DFS. Multivariate analysis revealed that pathological stages III-IV (HR=0.442, 95% CI=0.236-0.827, p=0.011), vascular invasion (HR=2.182, 95% CI=1.243-3.829, p=0.007), and the high-ΔSII group (HR=4.301, 95% CI=2.517-7.350, p<0.001) were independent predictors for OS. Adjuvant therapy (HR=0.415, 95% CI=0.250-0.687, p=0.001), vascular invasion (HR=3.305, 95% CI=1.944-5.620, p<0.001), and the high-ΔSII group (HR=4.924, 95% CI=2.992-8.102, p<0.001) were significant prognostic factors for DFS. Conclusions. The present study demonstrated that ∆SII was associated with the clinical outcome in CRC patients undergoing curative resection, supporting the role of ∆SII as a prognostic biomarker.http://dx.doi.org/10.1155/2020/4105809 |
| spellingShingle | Qingqing Chen Haohao Wu Xinwei Guo Ke Gu Wenjie Wang Xiaochen Chen Shengjun Ji Hui Yang Jiahao Zhu The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection Mediators of Inflammation |
| title | The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection |
| title_full | The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection |
| title_fullStr | The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection |
| title_full_unstemmed | The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection |
| title_short | The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection |
| title_sort | change of systemic immune inflammation index independently predicts survival of colorectal cancer patients after curative resection |
| url | http://dx.doi.org/10.1155/2020/4105809 |
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