Liver Failure with Marked Hyperferritinemia: ‘Ironing Out’ the Diagnosis
Hemophagocytic lymphohistiocytosis (HLH) may manifest as neonatal liver failure characterized by hepatosplenomegaly, profound coagulopathy, ascites and hyperbilirubinemia. Marked hyperferritinemia may be present in these patients, mimicking perinatal hemochromatosis. Tissue specimens are critical in...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2001/651470 |
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| _version_ | 1832559858033885184 |
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| author | Susan E Natsheh Eve A Roberts Bo Ngan Peter Chait Vicky Lee Ng |
| author_facet | Susan E Natsheh Eve A Roberts Bo Ngan Peter Chait Vicky Lee Ng |
| author_sort | Susan E Natsheh |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) may manifest as neonatal liver failure characterized by hepatosplenomegaly, profound coagulopathy, ascites and hyperbilirubinemia. Marked hyperferritinemia may be present in these patients, mimicking perinatal hemochromatosis. Tissue specimens are critical in distinguishing these two diseases and in directing management. Clinical recognition and diagnosis of HLH can be difficult but are crucial for appropriate therapy and genetic counselling. Liver transplantation is absolutely contraindicated for patients with HLH but may be the only life-saving treatment modality for patients with perinatal hemochromatosis. |
| format | Article |
| id | doaj-art-bfc2c76f3c8842b2873712e1520d103c |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-bfc2c76f3c8842b2873712e1520d103c2025-02-03T01:29:11ZengWileyCanadian Journal of Gastroenterology0835-79002001-01-0115853754010.1155/2001/651470Liver Failure with Marked Hyperferritinemia: ‘Ironing Out’ the DiagnosisSusan E Natsheh0Eve A Roberts1Bo Ngan2Peter Chait3Vicky Lee Ng4Department of Paediatrics, Division of Gastroenterology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Paediatrics, Division of Gastroenterology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Pathology, The Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Radiology, The Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Paediatrics, Division of Gastroenterology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, CanadaHemophagocytic lymphohistiocytosis (HLH) may manifest as neonatal liver failure characterized by hepatosplenomegaly, profound coagulopathy, ascites and hyperbilirubinemia. Marked hyperferritinemia may be present in these patients, mimicking perinatal hemochromatosis. Tissue specimens are critical in distinguishing these two diseases and in directing management. Clinical recognition and diagnosis of HLH can be difficult but are crucial for appropriate therapy and genetic counselling. Liver transplantation is absolutely contraindicated for patients with HLH but may be the only life-saving treatment modality for patients with perinatal hemochromatosis.http://dx.doi.org/10.1155/2001/651470 |
| spellingShingle | Susan E Natsheh Eve A Roberts Bo Ngan Peter Chait Vicky Lee Ng Liver Failure with Marked Hyperferritinemia: ‘Ironing Out’ the Diagnosis Canadian Journal of Gastroenterology |
| title | Liver Failure with Marked Hyperferritinemia: ‘Ironing Out’ the Diagnosis |
| title_full | Liver Failure with Marked Hyperferritinemia: ‘Ironing Out’ the Diagnosis |
| title_fullStr | Liver Failure with Marked Hyperferritinemia: ‘Ironing Out’ the Diagnosis |
| title_full_unstemmed | Liver Failure with Marked Hyperferritinemia: ‘Ironing Out’ the Diagnosis |
| title_short | Liver Failure with Marked Hyperferritinemia: ‘Ironing Out’ the Diagnosis |
| title_sort | liver failure with marked hyperferritinemia ironing out the diagnosis |
| url | http://dx.doi.org/10.1155/2001/651470 |
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