Injectable Chitosan Hydrogel Particles as Nasal Packing Materials After Endoscopic Sinus Surgery for Treatment of Chronic Sinusitis
After endoscopic sinus surgery (ESS), nasal packing is often used to stop bleeding and promote wound healing. Because maintaining a moist environment is important to enhance wound healing, hydrogel-based wound dressings are effective to promote wound healing. Chitosan is used in the medical field be...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/11/1/60 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588441025511424 |
|---|---|
| author | Yusuke Yamashita Kei Hosoya Yukio Fujiwara Yoichi Saito Masahiro Yoshida Shoji Matsune Kimihiro Okubo Takayuki Takei |
| author_facet | Yusuke Yamashita Kei Hosoya Yukio Fujiwara Yoichi Saito Masahiro Yoshida Shoji Matsune Kimihiro Okubo Takayuki Takei |
| author_sort | Yusuke Yamashita |
| collection | DOAJ |
| description | After endoscopic sinus surgery (ESS), nasal packing is often used to stop bleeding and promote wound healing. Because maintaining a moist environment is important to enhance wound healing, hydrogel-based wound dressings are effective to promote wound healing. Chitosan is used in the medical field because of its high hemostatic and wound healing properties. We developed a pH-neutral and non-toxic chitosan hydrogel, which was difficult to achieve using conventional methods. In this study, we show in animal experiments that the chitosan hydrogel (hydrogel particles) had higher wound healing properties than a commercially available solid wound dressing (dry state) composed of the same polymer. Additionally, we applied the injectable chitosan hydrogel particles as nasal packing materials to patients with bilateral chronic sinusitis undergoing ESS in a pilot clinical study. Concerning symptom scores, though the results narrowly missed statistical differences (<i>p</i> < 0.05), the average scores of our chitosan hydrogel were superior to those of a commercially available wound dressing (especially <i>p</i> = 0.09 for nasal bleeding). These findings suggest that the injectable chitosan hydrogel could be a viable option as a packing material following ESS. |
| format | Article |
| id | doaj-art-bfbf5612596a4e84ad030bef617f71f6 |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-bfbf5612596a4e84ad030bef617f71f62025-01-24T13:33:58ZengMDPI AGGels2310-28612025-01-011116010.3390/gels11010060Injectable Chitosan Hydrogel Particles as Nasal Packing Materials After Endoscopic Sinus Surgery for Treatment of Chronic SinusitisYusuke Yamashita0Kei Hosoya1Yukio Fujiwara2Yoichi Saito3Masahiro Yoshida4Shoji Matsune5Kimihiro Okubo6Takayuki Takei7Department of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, JapanNose and Smell Clinic Ikebukuro, Tokyo 171-0022, JapanDepartment of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, JapanLaboratory of Bioengineering, Faculty of Advanced Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, JapanDepartment of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, JapanDepartment of Otolaryngology, Musashi Kosugi Hospital, Nippon Medical School, Kanagawa 211-8533, JapanDepartment of Otorhinolaryngology, Nippon Medical School, Tokyo 113-8602, JapanDepartment of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, JapanAfter endoscopic sinus surgery (ESS), nasal packing is often used to stop bleeding and promote wound healing. Because maintaining a moist environment is important to enhance wound healing, hydrogel-based wound dressings are effective to promote wound healing. Chitosan is used in the medical field because of its high hemostatic and wound healing properties. We developed a pH-neutral and non-toxic chitosan hydrogel, which was difficult to achieve using conventional methods. In this study, we show in animal experiments that the chitosan hydrogel (hydrogel particles) had higher wound healing properties than a commercially available solid wound dressing (dry state) composed of the same polymer. Additionally, we applied the injectable chitosan hydrogel particles as nasal packing materials to patients with bilateral chronic sinusitis undergoing ESS in a pilot clinical study. Concerning symptom scores, though the results narrowly missed statistical differences (<i>p</i> < 0.05), the average scores of our chitosan hydrogel were superior to those of a commercially available wound dressing (especially <i>p</i> = 0.09 for nasal bleeding). These findings suggest that the injectable chitosan hydrogel could be a viable option as a packing material following ESS.https://www.mdpi.com/2310-2861/11/1/60endoscopic sinus surgerychronic sinusitisnasal packingchitosanhydrogelhemostasis |
| spellingShingle | Yusuke Yamashita Kei Hosoya Yukio Fujiwara Yoichi Saito Masahiro Yoshida Shoji Matsune Kimihiro Okubo Takayuki Takei Injectable Chitosan Hydrogel Particles as Nasal Packing Materials After Endoscopic Sinus Surgery for Treatment of Chronic Sinusitis Gels endoscopic sinus surgery chronic sinusitis nasal packing chitosan hydrogel hemostasis |
| title | Injectable Chitosan Hydrogel Particles as Nasal Packing Materials After Endoscopic Sinus Surgery for Treatment of Chronic Sinusitis |
| title_full | Injectable Chitosan Hydrogel Particles as Nasal Packing Materials After Endoscopic Sinus Surgery for Treatment of Chronic Sinusitis |
| title_fullStr | Injectable Chitosan Hydrogel Particles as Nasal Packing Materials After Endoscopic Sinus Surgery for Treatment of Chronic Sinusitis |
| title_full_unstemmed | Injectable Chitosan Hydrogel Particles as Nasal Packing Materials After Endoscopic Sinus Surgery for Treatment of Chronic Sinusitis |
| title_short | Injectable Chitosan Hydrogel Particles as Nasal Packing Materials After Endoscopic Sinus Surgery for Treatment of Chronic Sinusitis |
| title_sort | injectable chitosan hydrogel particles as nasal packing materials after endoscopic sinus surgery for treatment of chronic sinusitis |
| topic | endoscopic sinus surgery chronic sinusitis nasal packing chitosan hydrogel hemostasis |
| url | https://www.mdpi.com/2310-2861/11/1/60 |
| work_keys_str_mv | AT yusukeyamashita injectablechitosanhydrogelparticlesasnasalpackingmaterialsafterendoscopicsinussurgeryfortreatmentofchronicsinusitis AT keihosoya injectablechitosanhydrogelparticlesasnasalpackingmaterialsafterendoscopicsinussurgeryfortreatmentofchronicsinusitis AT yukiofujiwara injectablechitosanhydrogelparticlesasnasalpackingmaterialsafterendoscopicsinussurgeryfortreatmentofchronicsinusitis AT yoichisaito injectablechitosanhydrogelparticlesasnasalpackingmaterialsafterendoscopicsinussurgeryfortreatmentofchronicsinusitis AT masahiroyoshida injectablechitosanhydrogelparticlesasnasalpackingmaterialsafterendoscopicsinussurgeryfortreatmentofchronicsinusitis AT shojimatsune injectablechitosanhydrogelparticlesasnasalpackingmaterialsafterendoscopicsinussurgeryfortreatmentofchronicsinusitis AT kimihirookubo injectablechitosanhydrogelparticlesasnasalpackingmaterialsafterendoscopicsinussurgeryfortreatmentofchronicsinusitis AT takayukitakei injectablechitosanhydrogelparticlesasnasalpackingmaterialsafterendoscopicsinussurgeryfortreatmentofchronicsinusitis |