MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling
MHC class I molecules are key in the presentation of antigen and initiation of adaptive CD8+ T cell responses. In addition to its classical activity, MHC I may possess nonclassical functions. We have previously identified a regulatory role of MHC I in TLR signaling and antibacterial immunity. Howeve...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/5370706 |
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| author | Simo Xia Yijie Tao Likun Cui Yizhi Yu Sheng Xu |
| author_facet | Simo Xia Yijie Tao Likun Cui Yizhi Yu Sheng Xu |
| author_sort | Simo Xia |
| collection | DOAJ |
| description | MHC class I molecules are key in the presentation of antigen and initiation of adaptive CD8+ T cell responses. In addition to its classical activity, MHC I may possess nonclassical functions. We have previously identified a regulatory role of MHC I in TLR signaling and antibacterial immunity. However, its role in innate antiviral immunity remains unknown. In this study, we found a reduced viral load in MHC I-deficient macrophages that was independent of type I IFN production. Mechanically, MHC I mediated viral suppression by inhibiting the type I IFN signaling pathway, which depends on SHP2. Cross-linking MHC I at the membrane increased SHP2 activation and further suppressed STAT1 phosphorylation. Therefore, our data revealed an inhibitory role of MHC I in type I IFN response to viral infection and expanded our understanding of MHC I and antigen presentation. |
| format | Article |
| id | doaj-art-bfbaa7a803d541a8aac41acc51e63d3d |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-bfbaa7a803d541a8aac41acc51e63d3d2025-02-03T01:24:16ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/53707065370706MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon SignalingSimo Xia0Yijie Tao1Likun Cui2Yizhi Yu3Sheng Xu4National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai 200433, ChinaNational Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai 200433, ChinaNational Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai 200433, ChinaNational Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai 200433, ChinaNational Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai 200433, ChinaMHC class I molecules are key in the presentation of antigen and initiation of adaptive CD8+ T cell responses. In addition to its classical activity, MHC I may possess nonclassical functions. We have previously identified a regulatory role of MHC I in TLR signaling and antibacterial immunity. However, its role in innate antiviral immunity remains unknown. In this study, we found a reduced viral load in MHC I-deficient macrophages that was independent of type I IFN production. Mechanically, MHC I mediated viral suppression by inhibiting the type I IFN signaling pathway, which depends on SHP2. Cross-linking MHC I at the membrane increased SHP2 activation and further suppressed STAT1 phosphorylation. Therefore, our data revealed an inhibitory role of MHC I in type I IFN response to viral infection and expanded our understanding of MHC I and antigen presentation.http://dx.doi.org/10.1155/2019/5370706 |
| spellingShingle | Simo Xia Yijie Tao Likun Cui Yizhi Yu Sheng Xu MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling Journal of Immunology Research |
| title | MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling |
| title_full | MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling |
| title_fullStr | MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling |
| title_full_unstemmed | MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling |
| title_short | MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling |
| title_sort | mhc class i molecules exacerbate viral infection by disrupting type i interferon signaling |
| url | http://dx.doi.org/10.1155/2019/5370706 |
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