Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother–child cohort
Abstract The evidence regarding the association between infant formula (IF) composition and the prevention of allergy and respiratory diseases remains sparse and inconclusive. This study aimed to evaluate whether some IF characteristics were associated with the risk of allergy or respiratory disease...
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| Format: | Article |
| Language: | English |
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Wiley
2024-10-01
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| Series: | Maternal and Child Nutrition |
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| Online Access: | https://doi.org/10.1111/mcn.13673 |
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| author | Moufidath Adjibade Lucille Vigneron Rosalie Delvert Karine Adel‐Patient Amandine Divaret‐Chauveau Isabella Annesi‐Maesano Barbara Heude Marie‐Aline Charles Blandine deLauzon‐Guillain |
| author_facet | Moufidath Adjibade Lucille Vigneron Rosalie Delvert Karine Adel‐Patient Amandine Divaret‐Chauveau Isabella Annesi‐Maesano Barbara Heude Marie‐Aline Charles Blandine deLauzon‐Guillain |
| author_sort | Moufidath Adjibade |
| collection | DOAJ |
| description | Abstract The evidence regarding the association between infant formula (IF) composition and the prevention of allergy and respiratory diseases remains sparse and inconclusive. This study aimed to evaluate whether some IF characteristics were associated with the risk of allergy or respiratory diseases in childhood. Among 1243 formula‐fed children from the EDEN mother–child cohort, IF characteristics concerning long‐chain polyunsaturated fatty acids (LCPUFAs) enrichment, prebiotic/probiotic enrichment, and hydrolysis of proteins were identified from the ingredients list. Eczema, wheezing, food allergy, asthma, and allergic rhinitis up to age 8 years were prospectively collected and summarized into four allergic and respiratory multimorbidity clusters. Associations between 4‐month IF characteristics and risk of allergy or respiratory diseases were tested using logistic regressions adjusted on main confounders. The consumption of LCPUFA‐enriched formula was not linked to allergic and respiratory multimorbidity clusters, but to a lower risk of any allergy, eczema, and wheezing. Probiotic‐enriched formula consumption was associated with a lower risk of belonging to the ‘Allergy without asthma’ cluster (odds ratio [OR] [95% confidence interval, CI] = 0.63 [0.40–0.99]), and consumption of a formula enriched in Bifidobacterium lactis was associated with a lower risk of any allergy (OR [95% CI] = 0.59 [0.41–0.85]). Partially hydrolysed formula (pHF) consumption was associated with a higher risk of belonging to the ‘Allergy without asthma’ cluster (OR [95% CI] = 2.73 [1.65–4.51]). This study confirms the positive association between pHF consumption and the risk of allergy found in previous observational studies and suggests that consumption of LCPUFA‐enriched or probiotic‐enriched formula was associated with a lower risk of allergy. |
| format | Article |
| id | doaj-art-bfad5b52c39f4221b9c76bc18a6247d6 |
| institution | Kabale University |
| issn | 1740-8695 1740-8709 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Maternal and Child Nutrition |
| spelling | doaj-art-bfad5b52c39f4221b9c76bc18a6247d62024-11-19T11:34:12ZengWileyMaternal and Child Nutrition1740-86951740-87092024-10-01204n/an/a10.1111/mcn.13673Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother–child cohortMoufidath Adjibade0Lucille Vigneron1Rosalie Delvert2Karine Adel‐Patient3Amandine Divaret‐Chauveau4Isabella Annesi‐Maesano5Barbara Heude6Marie‐Aline Charles7Blandine deLauzon‐Guillain8Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, CRESS Paris FranceUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, CRESS Paris FranceUniversité Paris‐Saclay, UVSQ, Univ. Paris‐Sud, Inserm, Équipe d'Épidémiologie respiratoire intégrative, CESP Villejuif FranceUniversité Paris‐Saclay, CEA, INRAE, DMTS Gif‐sur‐Yvette FranceUR 3450, Laboratoire DevAH, Université de Lorraine Vandoeuvre‐lès‐Nancy FranceDesbrest Institute of Epidemiology and Public Health (IDESP), Montpellier University and INSERM Montpellier FranceUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, CRESS Paris FranceUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, CRESS Paris FranceUniversité Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, CRESS Paris FranceAbstract The evidence regarding the association between infant formula (IF) composition and the prevention of allergy and respiratory diseases remains sparse and inconclusive. This study aimed to evaluate whether some IF characteristics were associated with the risk of allergy or respiratory diseases in childhood. Among 1243 formula‐fed children from the EDEN mother–child cohort, IF characteristics concerning long‐chain polyunsaturated fatty acids (LCPUFAs) enrichment, prebiotic/probiotic enrichment, and hydrolysis of proteins were identified from the ingredients list. Eczema, wheezing, food allergy, asthma, and allergic rhinitis up to age 8 years were prospectively collected and summarized into four allergic and respiratory multimorbidity clusters. Associations between 4‐month IF characteristics and risk of allergy or respiratory diseases were tested using logistic regressions adjusted on main confounders. The consumption of LCPUFA‐enriched formula was not linked to allergic and respiratory multimorbidity clusters, but to a lower risk of any allergy, eczema, and wheezing. Probiotic‐enriched formula consumption was associated with a lower risk of belonging to the ‘Allergy without asthma’ cluster (odds ratio [OR] [95% confidence interval, CI] = 0.63 [0.40–0.99]), and consumption of a formula enriched in Bifidobacterium lactis was associated with a lower risk of any allergy (OR [95% CI] = 0.59 [0.41–0.85]). Partially hydrolysed formula (pHF) consumption was associated with a higher risk of belonging to the ‘Allergy without asthma’ cluster (OR [95% CI] = 2.73 [1.65–4.51]). This study confirms the positive association between pHF consumption and the risk of allergy found in previous observational studies and suggests that consumption of LCPUFA‐enriched or probiotic‐enriched formula was associated with a lower risk of allergy.https://doi.org/10.1111/mcn.13673allergyinfant formulalong‐chain polyunsaturated fatty acidspartially hydrolysed formulaprobiotics |
| spellingShingle | Moufidath Adjibade Lucille Vigneron Rosalie Delvert Karine Adel‐Patient Amandine Divaret‐Chauveau Isabella Annesi‐Maesano Barbara Heude Marie‐Aline Charles Blandine deLauzon‐Guillain Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother–child cohort Maternal and Child Nutrition allergy infant formula long‐chain polyunsaturated fatty acids partially hydrolysed formula probiotics |
| title | Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother–child cohort |
| title_full | Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother–child cohort |
| title_fullStr | Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother–child cohort |
| title_full_unstemmed | Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother–child cohort |
| title_short | Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother–child cohort |
| title_sort | characteristics of infant formula consumed in the first months of life and allergy in the eden mother child cohort |
| topic | allergy infant formula long‐chain polyunsaturated fatty acids partially hydrolysed formula probiotics |
| url | https://doi.org/10.1111/mcn.13673 |
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