Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury
Increasing concern on chronic radiation injuries should be treated properly for life-saving improvement of wound management and quality of life. Recently, regenerative surgical modalities should be attempted with the use of noncultured autologous adipose-derived stem cells (ADSCs) with temporal arti...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2010/532704 |
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| _version_ | 1832551361964670976 |
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| author | Sadanori Akita Kozo Akino Akiyoshi Hirano Akira Ohtsuru Shunichi Yamashita |
| author_facet | Sadanori Akita Kozo Akino Akiyoshi Hirano Akira Ohtsuru Shunichi Yamashita |
| author_sort | Sadanori Akita |
| collection | DOAJ |
| description | Increasing concern on chronic radiation injuries should be treated properly for life-saving improvement of wound management and quality of life. Recently, regenerative surgical modalities should be attempted with the use of noncultured autologous adipose-derived stem cells (ADSCs) with temporal artificial dermis impregnated and sprayed with local angiogenic factor such as basic fibroblast growth factor, and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Autologous adipose-derived stem cells, together with angiogenic and mitogenic factor of basic fibroblast growth factor and an artificial dermis, were applied over the excised irradiated skin defect and tested for Patients who were uneventfully healed with minimal donor-site morbidity, which lasts more than 1.5 years. |
| format | Article |
| id | doaj-art-bfa8728f6f3044db91c49a38e6528cc7 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-bfa8728f6f3044db91c49a38e6528cc72025-02-03T06:01:39ZengWileyStem Cells International1687-96782010-01-01201010.4061/2010/532704532704Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation InjurySadanori Akita0Kozo Akino1Akiyoshi Hirano2Akira Ohtsuru3Shunichi Yamashita4Department of Plastic and Reconstructive Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanDepartment of Plastic and Reconstructive Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanDepartment of Plastic and Reconstructive Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanTakashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital, Nagasaki 852-8501, JapanAtomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852-8501, JapanIncreasing concern on chronic radiation injuries should be treated properly for life-saving improvement of wound management and quality of life. Recently, regenerative surgical modalities should be attempted with the use of noncultured autologous adipose-derived stem cells (ADSCs) with temporal artificial dermis impregnated and sprayed with local angiogenic factor such as basic fibroblast growth factor, and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Autologous adipose-derived stem cells, together with angiogenic and mitogenic factor of basic fibroblast growth factor and an artificial dermis, were applied over the excised irradiated skin defect and tested for Patients who were uneventfully healed with minimal donor-site morbidity, which lasts more than 1.5 years.http://dx.doi.org/10.4061/2010/532704 |
| spellingShingle | Sadanori Akita Kozo Akino Akiyoshi Hirano Akira Ohtsuru Shunichi Yamashita Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury Stem Cells International |
| title | Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury |
| title_full | Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury |
| title_fullStr | Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury |
| title_full_unstemmed | Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury |
| title_short | Noncultured Autologous Adipose-Derived Stem Cells Therapy for Chronic Radiation Injury |
| title_sort | noncultured autologous adipose derived stem cells therapy for chronic radiation injury |
| url | http://dx.doi.org/10.4061/2010/532704 |
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