Primary Orbital Marginal Zone B-cell Lymphoma: A Rare Case Report
Orbital Lymphomas (OL) account for 1 to 2% of Non Hodgkin Lymphomas (NHLs) and 2 to 11% of all orbital tumours. The most common primary OL is low-grade marginal zone B-cell lymphoma. This is a case of primary orbital NHL mimicking an orbital pseudotumour. A 67-year-old male presented with a swolle...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2025-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/20594/74703_CE[Ra1]_F(SHU)_QC(PS_SS)_PF1(AG_SS)_PFA(IS)_PB(AG_IS)_PN(IS).pdf |
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| Summary: | Orbital Lymphomas (OL) account for 1 to 2% of Non Hodgkin Lymphomas (NHLs) and 2 to 11% of all orbital tumours. The most
common primary OL is low-grade marginal zone B-cell lymphoma. This is a case of primary orbital NHL mimicking an orbital
pseudotumour. A 67-year-old male presented with a swollen right eye associated with lacrimation for two months. On examination,
there was right eye proptosis. Thyroid, liver and renal function tests were within normal limits. Contrast Enhanced Computed
Tomography (CECT) revealed a homogenously enhancing intraconal mass measuring 4.1×3.2×2.8 cm, with features favouring a benign aetiology. Cytosmears revealed features suggestive of inflammatory pseudotumour of the orbit. Histopathological findings suggested low-grade NHL. Immunohistochemistry (IHC) showed positivity for CD20, CD79a, PAX5, and Bcl2, and negativity for CD3, CD5, CD10, CD23, Bcl6, and Cyclin-D1. Hence, a final diagnosis of marginal zone B-cell lymphoma was rendered. Detailed clinical and radiological evaluations did not reveal lymphadenopathy anywhere else or any other focus of tumour, indicating the primary origin of this tumour in the orbit. Primary NHL of the orbit is rare. It can occur in the orbit without any systemic features. It must be diagnosed early and can be treated with surgery and chemotherapy. |
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| ISSN: | 2249-782X 0973-709X |