Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults
Vitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation i...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/5719461 |
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| author | Leticia Elizondo-Montemayor Elena C. Castillo Carlos Rodríguez-López José R. Villarreal-Calderón Merit Gómez-Carmona Sofia Tenorio-Martínez Bianca Nieblas Gerardo García-Rivas |
| author_facet | Leticia Elizondo-Montemayor Elena C. Castillo Carlos Rodríguez-López José R. Villarreal-Calderón Merit Gómez-Carmona Sofia Tenorio-Martínez Bianca Nieblas Gerardo García-Rivas |
| author_sort | Leticia Elizondo-Montemayor |
| collection | DOAJ |
| description | Vitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. The same cohort was followed during 12 months. Vitamin D deficiency/insufficiency was found in 91.3% of the subjects despite living in appropriate latitude (25°40′0″N). 25(OH)D levels remained below <30 ng/mL through all seasons. Vitamin D deficiency did not correlate to sun exposure or dietary intake. Gender was the strongest associated factor, explaining a variance of 20%. Waist circumference (WC) greater than 88 cm was a risk factor for vitamin D deficiency. Age (>74 years) combined with WC (>88 cm) and BMI (>32.7) showed a high probability (90%) of vitamin D deficiency. Remarkably, an increase in one centimeter in WC decreased 25(OH)D by 0.176 ng/mL, while an increase in one point BMI decreased 25(OH)D by 0.534 ng/mL. A cutoff point of 74 years of age determined probability of vitamin D hipovitaminosis. Vitamin D deficiency was correlated with TNF-α serum levels, possibly increasing the susceptibility of older adults to a proinflammatory state and its related diseases. |
| format | Article |
| id | doaj-art-bf9675dc3afb4e7fae49ed823ba79278 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-bf9675dc3afb4e7fae49ed823ba792782025-02-03T05:46:10ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/57194615719461Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older AdultsLeticia Elizondo-Montemayor0Elena C. Castillo1Carlos Rodríguez-López2José R. Villarreal-Calderón3Merit Gómez-Carmona4Sofia Tenorio-Martínez5Bianca Nieblas6Gerardo García-Rivas7Centro de Investigación en Nutrición Clínica y Obesidad, Escuela de Medicina, Tecnologico de Monterrey, 64849 Monterrey, NL, MexicoCentro de Investigación Biomédica, Hospital Zambrano Hellion, Tecnologico de Monterrey, 66278 San Pedro Garza-García, NL, MexicoCentro de Investigación Biomédica, Hospital Zambrano Hellion, Tecnologico de Monterrey, 66278 San Pedro Garza-García, NL, MexicoCentro de Investigación en Nutrición Clínica y Obesidad, Escuela de Medicina, Tecnologico de Monterrey, 64849 Monterrey, NL, MexicoCentro de Investigación en Nutrición Clínica y Obesidad, Escuela de Medicina, Tecnologico de Monterrey, 64849 Monterrey, NL, MexicoCentro de Investigación en Nutrición Clínica y Obesidad, Escuela de Medicina, Tecnologico de Monterrey, 64849 Monterrey, NL, MexicoCentro de Investigación en Nutrición Clínica y Obesidad, Escuela de Medicina, Tecnologico de Monterrey, 64849 Monterrey, NL, MexicoCentro de Investigación Biomédica, Hospital Zambrano Hellion, Tecnologico de Monterrey, 66278 San Pedro Garza-García, NL, MexicoVitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. The same cohort was followed during 12 months. Vitamin D deficiency/insufficiency was found in 91.3% of the subjects despite living in appropriate latitude (25°40′0″N). 25(OH)D levels remained below <30 ng/mL through all seasons. Vitamin D deficiency did not correlate to sun exposure or dietary intake. Gender was the strongest associated factor, explaining a variance of 20%. Waist circumference (WC) greater than 88 cm was a risk factor for vitamin D deficiency. Age (>74 years) combined with WC (>88 cm) and BMI (>32.7) showed a high probability (90%) of vitamin D deficiency. Remarkably, an increase in one centimeter in WC decreased 25(OH)D by 0.176 ng/mL, while an increase in one point BMI decreased 25(OH)D by 0.534 ng/mL. A cutoff point of 74 years of age determined probability of vitamin D hipovitaminosis. Vitamin D deficiency was correlated with TNF-α serum levels, possibly increasing the susceptibility of older adults to a proinflammatory state and its related diseases.http://dx.doi.org/10.1155/2017/5719461 |
| spellingShingle | Leticia Elizondo-Montemayor Elena C. Castillo Carlos Rodríguez-López José R. Villarreal-Calderón Merit Gómez-Carmona Sofia Tenorio-Martínez Bianca Nieblas Gerardo García-Rivas Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults Mediators of Inflammation |
| title | Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults |
| title_full | Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults |
| title_fullStr | Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults |
| title_full_unstemmed | Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults |
| title_short | Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults |
| title_sort | seasonal variation in vitamin d in association with age inflammatory cytokines anthropometric parameters and lifestyle factors in older adults |
| url | http://dx.doi.org/10.1155/2017/5719461 |
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