X-Chromosome Inactivation and Related Diseases
X-chromosome inactivation (XCI) is the form of dosage compensation in mammalian female cells to balance X-linked gene expression levels of the two sexes. Many diseases are related to XCI due to inactivation escape and skewing, and the symptoms and severity of these diseases also largely depend on th...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/2022/1391807 |
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| _version_ | 1832564912145039360 |
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| author | Zhuo Sun Jinbo Fan Yang Wang |
| author_facet | Zhuo Sun Jinbo Fan Yang Wang |
| author_sort | Zhuo Sun |
| collection | DOAJ |
| description | X-chromosome inactivation (XCI) is the form of dosage compensation in mammalian female cells to balance X-linked gene expression levels of the two sexes. Many diseases are related to XCI due to inactivation escape and skewing, and the symptoms and severity of these diseases also largely depend on the status of XCI. They can be divided into 3 types: X-linked diseases, diseases that are affected by XCI escape, and X-chromosome aneuploidy. Here, we review representative diseases in terms of their definition, symptoms, and XCI’s role in the pathogenesis of these diseases. |
| format | Article |
| id | doaj-art-bf93e40895534c56842fa7d324e01e06 |
| institution | Kabale University |
| issn | 1469-5073 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-bf93e40895534c56842fa7d324e01e062025-02-03T01:09:51ZengWileyGenetics Research1469-50732022-01-01202210.1155/2022/1391807X-Chromosome Inactivation and Related DiseasesZhuo Sun0Jinbo Fan1Yang Wang2Xi’an Key Laboratory of Pathogenic Microorganism and Tumor ImmunityXi’an Key Laboratory of Pathogenic Microorganism and Tumor ImmunityXi’an Key Laboratory of Pathogenic Microorganism and Tumor ImmunityX-chromosome inactivation (XCI) is the form of dosage compensation in mammalian female cells to balance X-linked gene expression levels of the two sexes. Many diseases are related to XCI due to inactivation escape and skewing, and the symptoms and severity of these diseases also largely depend on the status of XCI. They can be divided into 3 types: X-linked diseases, diseases that are affected by XCI escape, and X-chromosome aneuploidy. Here, we review representative diseases in terms of their definition, symptoms, and XCI’s role in the pathogenesis of these diseases.http://dx.doi.org/10.1155/2022/1391807 |
| spellingShingle | Zhuo Sun Jinbo Fan Yang Wang X-Chromosome Inactivation and Related Diseases Genetics Research |
| title | X-Chromosome Inactivation and Related Diseases |
| title_full | X-Chromosome Inactivation and Related Diseases |
| title_fullStr | X-Chromosome Inactivation and Related Diseases |
| title_full_unstemmed | X-Chromosome Inactivation and Related Diseases |
| title_short | X-Chromosome Inactivation and Related Diseases |
| title_sort | x chromosome inactivation and related diseases |
| url | http://dx.doi.org/10.1155/2022/1391807 |
| work_keys_str_mv | AT zhuosun xchromosomeinactivationandrelateddiseases AT jinbofan xchromosomeinactivationandrelateddiseases AT yangwang xchromosomeinactivationandrelateddiseases |