Identification of prospective novel drug targets for immune thrombocytopenia by integrating plasma proteome

Identification of prospective novel drug targets for immune thrombocytopenia by integrating plasma proteome

Objectives The etiology of immune thrombocytopenia (ITP) is heterogeneous and intricate, with some unresponsive to current treatments. We used Mendelian randomization (MR) to identify new therapeutic targets.Methods Genetic instruments for 2923 plasma proteins from the UKBPPP study and ITP data from...

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Bibliographic Details
Main Authors: Wei He, Jingcheng Zhang, Mingzhe Zhao, Jinyong Fang, Fang He, Caifang Zhao
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Hematology
Subjects:
Mendelian randomization
immune thrombocytopenia
plasma protein
drug target
genome-wide study
protein-protein interaction
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2025.2545645
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