Azole-Induced Myositis after Combined Lung-Liver Transplantation
Lung transplant recipients experience a high rate of invasive pulmonary aspergillosis infections, for which voriconazole is the treatment of choice. We report a patient who developed voriconazole-induced myositis that relapsed after one dose of isavuconazole. Our patient was a 38-year-old man who re...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2022/7323755 |
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| author | Sofie Happaerts Michiel Wieërs Ward Vander Mijnsbrugge Laurent Godinas Dirk Van Raemdonck Laurens J. Ceulemans Robin Vos Geert M. Verleden |
| author_facet | Sofie Happaerts Michiel Wieërs Ward Vander Mijnsbrugge Laurent Godinas Dirk Van Raemdonck Laurens J. Ceulemans Robin Vos Geert M. Verleden |
| author_sort | Sofie Happaerts |
| collection | DOAJ |
| description | Lung transplant recipients experience a high rate of invasive pulmonary aspergillosis infections, for which voriconazole is the treatment of choice. We report a patient who developed voriconazole-induced myositis that relapsed after one dose of isavuconazole. Our patient was a 38-year-old man who received a single sequential lung transplantation and liver transplantation because of end-stage cystic fibrosis. He presented to our emergency room with acute pain in both forearms at 3 weeks after voriconazole was initiated for invasive pulmonary aspergillosis infection. Levels of voriconazole were normal during the course of therapy. After stopping voriconazole, the symptoms decreased but relapsed after one dose of isavuconazole. Other causes of muscle pain and inflammation were excluded. Magnetic resonance imaging of both arms showed muscle edema in both arms, including involvement of the fascia, consistent with myositis. There were no signs of necrosis. Isavuconazole was discontinued, and the corticosteroid dose was temporarily increased, with rapid resolution of all complaints. Our patient is the fourth reported case of voriconazole-induced myositis, and the first whose symptoms relapsed after initiating isavuconazole. |
| format | Article |
| id | doaj-art-bf781f25d7c34cc39fc97a292dc37167 |
| institution | Kabale University |
| issn | 2090-6951 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-bf781f25d7c34cc39fc97a292dc371672025-02-03T01:09:52ZengWileyCase Reports in Transplantation2090-69512022-01-01202210.1155/2022/7323755Azole-Induced Myositis after Combined Lung-Liver TransplantationSofie Happaerts0Michiel Wieërs1Ward Vander Mijnsbrugge2Laurent Godinas3Dirk Van Raemdonck4Laurens J. Ceulemans5Robin Vos6Geert M. Verleden7Department of Respiratory Diseases and Lung TransplantationDepartment of Respiratory Diseases and Lung TransplantationDepartment of RadiologyDepartment of Respiratory Diseases and Lung TransplantationDepartment of Thoracic Surgery and Lung TransplantationDepartment of Thoracic Surgery and Lung TransplantationDepartment of Respiratory Diseases and Lung TransplantationDepartment of Respiratory Diseases and Lung TransplantationLung transplant recipients experience a high rate of invasive pulmonary aspergillosis infections, for which voriconazole is the treatment of choice. We report a patient who developed voriconazole-induced myositis that relapsed after one dose of isavuconazole. Our patient was a 38-year-old man who received a single sequential lung transplantation and liver transplantation because of end-stage cystic fibrosis. He presented to our emergency room with acute pain in both forearms at 3 weeks after voriconazole was initiated for invasive pulmonary aspergillosis infection. Levels of voriconazole were normal during the course of therapy. After stopping voriconazole, the symptoms decreased but relapsed after one dose of isavuconazole. Other causes of muscle pain and inflammation were excluded. Magnetic resonance imaging of both arms showed muscle edema in both arms, including involvement of the fascia, consistent with myositis. There were no signs of necrosis. Isavuconazole was discontinued, and the corticosteroid dose was temporarily increased, with rapid resolution of all complaints. Our patient is the fourth reported case of voriconazole-induced myositis, and the first whose symptoms relapsed after initiating isavuconazole.http://dx.doi.org/10.1155/2022/7323755 |
| spellingShingle | Sofie Happaerts Michiel Wieërs Ward Vander Mijnsbrugge Laurent Godinas Dirk Van Raemdonck Laurens J. Ceulemans Robin Vos Geert M. Verleden Azole-Induced Myositis after Combined Lung-Liver Transplantation Case Reports in Transplantation |
| title | Azole-Induced Myositis after Combined Lung-Liver Transplantation |
| title_full | Azole-Induced Myositis after Combined Lung-Liver Transplantation |
| title_fullStr | Azole-Induced Myositis after Combined Lung-Liver Transplantation |
| title_full_unstemmed | Azole-Induced Myositis after Combined Lung-Liver Transplantation |
| title_short | Azole-Induced Myositis after Combined Lung-Liver Transplantation |
| title_sort | azole induced myositis after combined lung liver transplantation |
| url | http://dx.doi.org/10.1155/2022/7323755 |
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