Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory Cortex
Prolonged exposure to afferent stimulation (“adaptation”) can cause profound short-term changes in the responsiveness of cortical sensory neurons. While several models have been proposed that link adaptation to single-neuron dynamics, including GABAergic inhibition, the process is currently imperfec...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/5464096 |
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| author | Nicolaas A. J. Puts Richard A. E. Edden Suresh Muthukumaraswamy Krish D. Singh David J. McGonigle |
| author_facet | Nicolaas A. J. Puts Richard A. E. Edden Suresh Muthukumaraswamy Krish D. Singh David J. McGonigle |
| author_sort | Nicolaas A. J. Puts |
| collection | DOAJ |
| description | Prolonged exposure to afferent stimulation (“adaptation”) can cause profound short-term changes in the responsiveness of cortical sensory neurons. While several models have been proposed that link adaptation to single-neuron dynamics, including GABAergic inhibition, the process is currently imperfectly understood at the whole-brain level in humans. Here, we used magnetoencephalography (MEG) to examine the neurophysiological correlates of adaptation within SI in humans. In one condition, a 25 Hz adapting stimulus (5 s) was followed by a 1 s 25 Hz probe (“same”), and in a second condition, the adapting stimulus was followed by a 1 s 180 Hz probe (“different”). We hypothesized that changes in the mu-beta activity band (reflecting GABAergic processing) would be modulated differently between the “same” and “different” probe stimuli. We show that the primary somatosensory (SI) mu-beta response to the “same” probe is significantly reduced (p=0.014) compared to the adapting stimulus, whereas the mu-beta response to the “different” probe is not (p=n.s.). This reduction may reflect sharpening of the spatiotemporal pattern of activity after adaptation. The stimulus onset mu-beta response did not differ between a 25 Hz adapting stimulus and a 180 Hz probe, suggesting that the mu-beta response is independent of stimulus frequency. Furthermore, we show a sustained evoked and induced desynchronization for the duration of the adapting stimulus, consistent with invasive studies. Our findings are important in understanding the neurophysiology underlying short-term and stimulus-induced plasticity in the human brain and shows that the brain response to tactile stimulation is altered after only brief stimulation. |
| format | Article |
| id | doaj-art-bf74ca462dc24a86a7a0e3df20770b75 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-bf74ca462dc24a86a7a0e3df20770b752025-02-03T05:51:58ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/54640965464096Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory CortexNicolaas A. J. Puts0Richard A. E. Edden1Suresh Muthukumaraswamy2Krish D. Singh3David J. McGonigle4Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USARussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USACardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Maindy Road, Cardiff CF24 4HQ, UKCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Maindy Road, Cardiff CF24 4HQ, UKCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Maindy Road, Cardiff CF24 4HQ, UKProlonged exposure to afferent stimulation (“adaptation”) can cause profound short-term changes in the responsiveness of cortical sensory neurons. While several models have been proposed that link adaptation to single-neuron dynamics, including GABAergic inhibition, the process is currently imperfectly understood at the whole-brain level in humans. Here, we used magnetoencephalography (MEG) to examine the neurophysiological correlates of adaptation within SI in humans. In one condition, a 25 Hz adapting stimulus (5 s) was followed by a 1 s 25 Hz probe (“same”), and in a second condition, the adapting stimulus was followed by a 1 s 180 Hz probe (“different”). We hypothesized that changes in the mu-beta activity band (reflecting GABAergic processing) would be modulated differently between the “same” and “different” probe stimuli. We show that the primary somatosensory (SI) mu-beta response to the “same” probe is significantly reduced (p=0.014) compared to the adapting stimulus, whereas the mu-beta response to the “different” probe is not (p=n.s.). This reduction may reflect sharpening of the spatiotemporal pattern of activity after adaptation. The stimulus onset mu-beta response did not differ between a 25 Hz adapting stimulus and a 180 Hz probe, suggesting that the mu-beta response is independent of stimulus frequency. Furthermore, we show a sustained evoked and induced desynchronization for the duration of the adapting stimulus, consistent with invasive studies. Our findings are important in understanding the neurophysiology underlying short-term and stimulus-induced plasticity in the human brain and shows that the brain response to tactile stimulation is altered after only brief stimulation.http://dx.doi.org/10.1155/2019/5464096 |
| spellingShingle | Nicolaas A. J. Puts Richard A. E. Edden Suresh Muthukumaraswamy Krish D. Singh David J. McGonigle Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory Cortex Neural Plasticity |
| title | Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory Cortex |
| title_full | Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory Cortex |
| title_fullStr | Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory Cortex |
| title_full_unstemmed | Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory Cortex |
| title_short | Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory Cortex |
| title_sort | induced and evoked properties of vibrotactile adaptation in the primary somatosensory cortex |
| url | http://dx.doi.org/10.1155/2019/5464096 |
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