Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity
Summary: Tripartite motif (TRIM) proteins are E3 ligases with modular structures involved in diverse cellular functions. Whether biomolecular condensation broadly regulates TRIM proteins remains unclear. Here, we systematically examine 75 TRIMs in mammalian cells and find that the majority can form...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725005376 |
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