Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention
Cardiopulmonary bypass (CPB) is a common technique in cardiac surgery but is associated with acute kidney injury (AKI), which carries considerable morbidity and mortality. In this review, we explore the range and definition of CPB-associated AKI and discuss the possible impact of different disease r...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2331062 |
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| author | Xutao Yang Li Zhu Hong Pan Yi Yang |
| author_facet | Xutao Yang Li Zhu Hong Pan Yi Yang |
| author_sort | Xutao Yang |
| collection | DOAJ |
| description | Cardiopulmonary bypass (CPB) is a common technique in cardiac surgery but is associated with acute kidney injury (AKI), which carries considerable morbidity and mortality. In this review, we explore the range and definition of CPB-associated AKI and discuss the possible impact of different disease recognition methods on research outcomes. Furthermore, we introduce the specialized equipment and procedural intricacies associated with CPB surgeries. Based on recent research, we discuss the potential pathogenesis of AKI that may result from CPB, including compromised perfusion and oxygenation, inflammatory activation, oxidative stress, coagulopathy, hemolysis, and endothelial damage. Finally, we explore current interventions aimed at preventing and attenuating renal impairment related to CPB, and presenting these measures from three perspectives: (1) avoiding CPB to eliminate the fundamental impact on renal function; (2) optimizing CPB by adjusting equipment parameters, optimizing surgical procedures, or using improved materials to mitigate kidney damage; (3) employing pharmacological or interventional measures targeting pathogenic factors. |
| format | Article |
| id | doaj-art-bf64710acb764b1a999452648f9c3f5e |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-bf64710acb764b1a999452648f9c3f5e2025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2331062Cardiopulmonary bypass associated acute kidney injury: better understanding and better preventionXutao Yang0Li Zhu1Hong Pan2Yi Yang3The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, ChinaThe Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, ChinaThe Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, ChinaThe Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, ChinaCardiopulmonary bypass (CPB) is a common technique in cardiac surgery but is associated with acute kidney injury (AKI), which carries considerable morbidity and mortality. In this review, we explore the range and definition of CPB-associated AKI and discuss the possible impact of different disease recognition methods on research outcomes. Furthermore, we introduce the specialized equipment and procedural intricacies associated with CPB surgeries. Based on recent research, we discuss the potential pathogenesis of AKI that may result from CPB, including compromised perfusion and oxygenation, inflammatory activation, oxidative stress, coagulopathy, hemolysis, and endothelial damage. Finally, we explore current interventions aimed at preventing and attenuating renal impairment related to CPB, and presenting these measures from three perspectives: (1) avoiding CPB to eliminate the fundamental impact on renal function; (2) optimizing CPB by adjusting equipment parameters, optimizing surgical procedures, or using improved materials to mitigate kidney damage; (3) employing pharmacological or interventional measures targeting pathogenic factors.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2331062Cardiopulmonary bypassacute kidney injurypathogenesisprevention |
| spellingShingle | Xutao Yang Li Zhu Hong Pan Yi Yang Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention Renal Failure Cardiopulmonary bypass acute kidney injury pathogenesis prevention |
| title | Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention |
| title_full | Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention |
| title_fullStr | Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention |
| title_full_unstemmed | Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention |
| title_short | Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention |
| title_sort | cardiopulmonary bypass associated acute kidney injury better understanding and better prevention |
| topic | Cardiopulmonary bypass acute kidney injury pathogenesis prevention |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2331062 |
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