Characteristics, pathogenic and therapeutic role of gut microbiota in immunoglobulin A nephropathy
Immunoglobulin A nephropathy (IgAN) is the most prevalent glomerulonephritis in the world, and it is one of the leading causes of end-stage kidney disease. It is now believed that the pathogenesis of IgAN is the mesangial deposition of immune complex containing galactose-deficient IgA1, resulting in...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1438683/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087256456757248 |
|---|---|
| author | Kaijin Yao Lingqian Zheng Wenmin Chen Yina Xie Chunling Liao Tianbiao Zhou |
| author_facet | Kaijin Yao Lingqian Zheng Wenmin Chen Yina Xie Chunling Liao Tianbiao Zhou |
| author_sort | Kaijin Yao |
| collection | DOAJ |
| description | Immunoglobulin A nephropathy (IgAN) is the most prevalent glomerulonephritis in the world, and it is one of the leading causes of end-stage kidney disease. It is now believed that the pathogenesis of IgAN is the mesangial deposition of immune complex containing galactose-deficient IgA1, resulting in glomerular injury. Current treatments for IgAN include supportive care and immunosuppressive therapy. A growing number of studies found that the gut microbiota in IgAN was dysregulated. Gut microbiota may be involved in the development and progression of IgAN through three main aspects: destruction of intestinal barrier, changes in metabolites and abnormal mucosal immunity. Interestingly, therapies by modulating the gut microbiota, such as fecal microbiota transplantation, antibiotic treatment, probiotic treatment, Chinese herbal medicine Zhen Wu Tang treatment, gluten-free diet, and hydroxychloroquine treatment, can improve IgAN. In this review, the alteration of gut microbiota in IgAN, potential pathogenic roles of gut microbiota on IgAN and potential approaches to treat IgAN by modulating the gut microbiota are summarized. |
| format | Article |
| id | doaj-art-bf4c7464dc18465a9aaf238914b3e38c |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-bf4c7464dc18465a9aaf238914b3e38c2025-02-06T07:09:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.14386831438683Characteristics, pathogenic and therapeutic role of gut microbiota in immunoglobulin A nephropathyKaijin YaoLingqian ZhengWenmin ChenYina XieChunling LiaoTianbiao ZhouImmunoglobulin A nephropathy (IgAN) is the most prevalent glomerulonephritis in the world, and it is one of the leading causes of end-stage kidney disease. It is now believed that the pathogenesis of IgAN is the mesangial deposition of immune complex containing galactose-deficient IgA1, resulting in glomerular injury. Current treatments for IgAN include supportive care and immunosuppressive therapy. A growing number of studies found that the gut microbiota in IgAN was dysregulated. Gut microbiota may be involved in the development and progression of IgAN through three main aspects: destruction of intestinal barrier, changes in metabolites and abnormal mucosal immunity. Interestingly, therapies by modulating the gut microbiota, such as fecal microbiota transplantation, antibiotic treatment, probiotic treatment, Chinese herbal medicine Zhen Wu Tang treatment, gluten-free diet, and hydroxychloroquine treatment, can improve IgAN. In this review, the alteration of gut microbiota in IgAN, potential pathogenic roles of gut microbiota on IgAN and potential approaches to treat IgAN by modulating the gut microbiota are summarized.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1438683/fullimmunoglobulin A nephropathygut microbiotadysbiosisimmune responsesmodulate |
| spellingShingle | Kaijin Yao Lingqian Zheng Wenmin Chen Yina Xie Chunling Liao Tianbiao Zhou Characteristics, pathogenic and therapeutic role of gut microbiota in immunoglobulin A nephropathy Frontiers in Immunology immunoglobulin A nephropathy gut microbiota dysbiosis immune responses modulate |
| title | Characteristics, pathogenic and therapeutic role of gut microbiota in immunoglobulin A nephropathy |
| title_full | Characteristics, pathogenic and therapeutic role of gut microbiota in immunoglobulin A nephropathy |
| title_fullStr | Characteristics, pathogenic and therapeutic role of gut microbiota in immunoglobulin A nephropathy |
| title_full_unstemmed | Characteristics, pathogenic and therapeutic role of gut microbiota in immunoglobulin A nephropathy |
| title_short | Characteristics, pathogenic and therapeutic role of gut microbiota in immunoglobulin A nephropathy |
| title_sort | characteristics pathogenic and therapeutic role of gut microbiota in immunoglobulin a nephropathy |
| topic | immunoglobulin A nephropathy gut microbiota dysbiosis immune responses modulate |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1438683/full |
| work_keys_str_mv | AT kaijinyao characteristicspathogenicandtherapeuticroleofgutmicrobiotainimmunoglobulinanephropathy AT lingqianzheng characteristicspathogenicandtherapeuticroleofgutmicrobiotainimmunoglobulinanephropathy AT wenminchen characteristicspathogenicandtherapeuticroleofgutmicrobiotainimmunoglobulinanephropathy AT yinaxie characteristicspathogenicandtherapeuticroleofgutmicrobiotainimmunoglobulinanephropathy AT chunlingliao characteristicspathogenicandtherapeuticroleofgutmicrobiotainimmunoglobulinanephropathy AT tianbiaozhou characteristicspathogenicandtherapeuticroleofgutmicrobiotainimmunoglobulinanephropathy |