Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies
Neurodegenerative diseases are currently among the most devastating diseases with no effective disease-modifying drugs in the market, with Alzheimer’s disease (AD) being the most prevalent. AD is a complex multifactorial neurodegenerative disorder characterized by progressive and severe cognitive im...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/1/128 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588930685337600 |
|---|---|
| author | Androulla N. Miliotou Andria Kotsoni Lefteris C. Zacharia |
| author_facet | Androulla N. Miliotou Andria Kotsoni Lefteris C. Zacharia |
| author_sort | Androulla N. Miliotou |
| collection | DOAJ |
| description | Neurodegenerative diseases are currently among the most devastating diseases with no effective disease-modifying drugs in the market, with Alzheimer’s disease (AD) being the most prevalent. AD is a complex multifactorial neurodegenerative disorder characterized by progressive and severe cognitive impairment and memory loss. It is the most common cause of progressive memory loss (dementia) in the elderly, and to date, there is no effective treatment to cure or slow disease progression substantially. The role of adrenergic receptors in the pathogenesis of Alzheimer’s disease and other tauopathies is poorly understood or investigated. Recently, some studies indicated a potential benefit of drugs acting on the adrenergic receptors for AD and dementias, although due to the heterogeneity of the drug classes used, the results on the whole remain inconclusive. The scope of this review article is to comprehensively review the literature on the possible role of adrenergic receptors in neurodegenerative diseases, stemming from the use of agonists and antagonists including antihypertensive and asthma drugs acting on the adrenergic receptors, but also from animal models and in vitro models where these receptors have been studied. Ultimately, we hope to obtain a better understanding of the role of these receptors, identify the gaps in knowledge, and explore the possibility of repurposing such drugs for AD, given their long history of use and safety. |
| format | Article |
| id | doaj-art-bf49feaa18d442ce859d42959a3aac5e |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-bf49feaa18d442ce859d42959a3aac5e2025-01-24T13:25:18ZengMDPI AGBiomolecules2218-273X2025-01-0115112810.3390/biom15010128Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative TherapiesAndroulla N. Miliotou0Andria Kotsoni1Lefteris C. Zacharia2Department of Health Sciences, School of Life and Health Sciences, University of Nicosia, 46 Makedonitissas Avenue, 2417 Nicosia, CyprusDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, 46 Makedonitissas Avenue, 2417 Nicosia, CyprusDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, 46 Makedonitissas Avenue, 2417 Nicosia, CyprusNeurodegenerative diseases are currently among the most devastating diseases with no effective disease-modifying drugs in the market, with Alzheimer’s disease (AD) being the most prevalent. AD is a complex multifactorial neurodegenerative disorder characterized by progressive and severe cognitive impairment and memory loss. It is the most common cause of progressive memory loss (dementia) in the elderly, and to date, there is no effective treatment to cure or slow disease progression substantially. The role of adrenergic receptors in the pathogenesis of Alzheimer’s disease and other tauopathies is poorly understood or investigated. Recently, some studies indicated a potential benefit of drugs acting on the adrenergic receptors for AD and dementias, although due to the heterogeneity of the drug classes used, the results on the whole remain inconclusive. The scope of this review article is to comprehensively review the literature on the possible role of adrenergic receptors in neurodegenerative diseases, stemming from the use of agonists and antagonists including antihypertensive and asthma drugs acting on the adrenergic receptors, but also from animal models and in vitro models where these receptors have been studied. Ultimately, we hope to obtain a better understanding of the role of these receptors, identify the gaps in knowledge, and explore the possibility of repurposing such drugs for AD, given their long history of use and safety.https://www.mdpi.com/2218-273X/15/1/128adrenergic receptorsAlzheimer’s diseaseneurodegenerationneuroinflammationtauopathiesbeta amyloid |
| spellingShingle | Androulla N. Miliotou Andria Kotsoni Lefteris C. Zacharia Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies Biomolecules adrenergic receptors Alzheimer’s disease neurodegeneration neuroinflammation tauopathies beta amyloid |
| title | Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies |
| title_full | Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies |
| title_fullStr | Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies |
| title_full_unstemmed | Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies |
| title_short | Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies |
| title_sort | deciphering the role of adrenergic receptors in alzheimer s disease paving the way for innovative therapies |
| topic | adrenergic receptors Alzheimer’s disease neurodegeneration neuroinflammation tauopathies beta amyloid |
| url | https://www.mdpi.com/2218-273X/15/1/128 |
| work_keys_str_mv | AT androullanmiliotou decipheringtheroleofadrenergicreceptorsinalzheimersdiseasepavingthewayforinnovativetherapies AT andriakotsoni decipheringtheroleofadrenergicreceptorsinalzheimersdiseasepavingthewayforinnovativetherapies AT lefterisczacharia decipheringtheroleofadrenergicreceptorsinalzheimersdiseasepavingthewayforinnovativetherapies |