Prevention of tuberculosis in cynomolgus macaques by an attenuated Mycobacterium tuberculosis vaccine candidate

Prevention of tuberculosis in cynomolgus macaques by an attenuated Mycobacterium tuberculosis vaccine candidate

Abstract The need for novel vaccination strategies to control tuberculosis (TB) is underscored by the limited and variable efficacy of the currently licensed vaccine, Bacille Calmette-Guerin (BCG). SigH is critical for Mycobacterium tuberculosis (Mtb) to mitigate oxidative stress, and in its absence...

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Main Authors: Dhiraj K. Singh, Mushtaq Ahmed, Sadia Akter, Vinay Shivanna, Allison N. Bucşan, Abhishek Mishra, Nadia A. Golden, Peter J. Didier, Lara A. Doyle, Shannan Hall-Ursone, Chad J. Roy, Garima Arora, Edward J. Dick, Chinnaswamy Jagannath, Smriti Mehra, Shabaana A. Khader, Deepak Kaushal
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57090-4
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