Neuroprotective Transcription Factors in Animal Models of Parkinson Disease

A number of transcription factors, including En1/2, Foxa1/2, Lmx1a/b, Nurr1, Otx2, and Pitx3, with key roles in midbrain dopaminergic (mDA) neuron development, also regulate adult mDA neuron survival and physiology. Mouse models with targeted disruption of some of these genes display several feature...

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Bibliographic Details
Main Authors: François-Xavier Blaudin de Thé, Hocine Rekaik, Alain Prochiantz, Julia Fuchs, Rajiv L. Joshi
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2016/6097107
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