Neuroprotective Transcription Factors in Animal Models of Parkinson Disease
A number of transcription factors, including En1/2, Foxa1/2, Lmx1a/b, Nurr1, Otx2, and Pitx3, with key roles in midbrain dopaminergic (mDA) neuron development, also regulate adult mDA neuron survival and physiology. Mouse models with targeted disruption of some of these genes display several feature...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/6097107 |
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| author | François-Xavier Blaudin de Thé Hocine Rekaik Alain Prochiantz Julia Fuchs Rajiv L. Joshi |
| author_facet | François-Xavier Blaudin de Thé Hocine Rekaik Alain Prochiantz Julia Fuchs Rajiv L. Joshi |
| author_sort | François-Xavier Blaudin de Thé |
| collection | DOAJ |
| description | A number of transcription factors, including En1/2, Foxa1/2, Lmx1a/b, Nurr1, Otx2, and Pitx3, with key roles in midbrain dopaminergic (mDA) neuron development, also regulate adult mDA neuron survival and physiology. Mouse models with targeted disruption of some of these genes display several features reminiscent of Parkinson disease (PD), in particular the selective and progressive loss of mDA neurons in the substantia nigra pars compacta (SNpc). The characterization of these animal models has provided valuable insights into various mechanisms of PD pathogenesis. Therefore, the dissection of the mechanisms and survival signalling pathways engaged by these transcription factors to protect mDA neuron from degeneration can suggest novel therapeutic strategies. The work on En1/2-mediated neuroprotection also highlights the potential of protein transduction technology for neuroprotective approaches in PD. |
| format | Article |
| id | doaj-art-bf32e04f1e9741b1acdcbdfeea52f41b |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-bf32e04f1e9741b1acdcbdfeea52f41b2025-02-03T01:20:41ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/60971076097107Neuroprotective Transcription Factors in Animal Models of Parkinson DiseaseFrançois-Xavier Blaudin de Thé0Hocine Rekaik1Alain Prochiantz2Julia Fuchs3Rajiv L. Joshi4Center for Interdisciplinary Research in Biology (CIRB), Labex Memolife, CNRS UMR 7241, INSERM U1050, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, FranceCenter for Interdisciplinary Research in Biology (CIRB), Labex Memolife, CNRS UMR 7241, INSERM U1050, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, FranceCenter for Interdisciplinary Research in Biology (CIRB), Labex Memolife, CNRS UMR 7241, INSERM U1050, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, FranceCenter for Interdisciplinary Research in Biology (CIRB), Labex Memolife, CNRS UMR 7241, INSERM U1050, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, FranceCenter for Interdisciplinary Research in Biology (CIRB), Labex Memolife, CNRS UMR 7241, INSERM U1050, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, FranceA number of transcription factors, including En1/2, Foxa1/2, Lmx1a/b, Nurr1, Otx2, and Pitx3, with key roles in midbrain dopaminergic (mDA) neuron development, also regulate adult mDA neuron survival and physiology. Mouse models with targeted disruption of some of these genes display several features reminiscent of Parkinson disease (PD), in particular the selective and progressive loss of mDA neurons in the substantia nigra pars compacta (SNpc). The characterization of these animal models has provided valuable insights into various mechanisms of PD pathogenesis. Therefore, the dissection of the mechanisms and survival signalling pathways engaged by these transcription factors to protect mDA neuron from degeneration can suggest novel therapeutic strategies. The work on En1/2-mediated neuroprotection also highlights the potential of protein transduction technology for neuroprotective approaches in PD.http://dx.doi.org/10.1155/2016/6097107 |
| spellingShingle | François-Xavier Blaudin de Thé Hocine Rekaik Alain Prochiantz Julia Fuchs Rajiv L. Joshi Neuroprotective Transcription Factors in Animal Models of Parkinson Disease Neural Plasticity |
| title | Neuroprotective Transcription Factors in Animal Models of Parkinson Disease |
| title_full | Neuroprotective Transcription Factors in Animal Models of Parkinson Disease |
| title_fullStr | Neuroprotective Transcription Factors in Animal Models of Parkinson Disease |
| title_full_unstemmed | Neuroprotective Transcription Factors in Animal Models of Parkinson Disease |
| title_short | Neuroprotective Transcription Factors in Animal Models of Parkinson Disease |
| title_sort | neuroprotective transcription factors in animal models of parkinson disease |
| url | http://dx.doi.org/10.1155/2016/6097107 |
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